Murphy, S. et al. (2022) Variations in COVID-19 vaccination uptake among people in receipt of psychotropic drugs: cross-sectional analysis of a national population-based prospective cohort. British Journal of Psychiatry, 221(1), pp. 417-424. (doi: 10.1192/bjp.2022.36) (PMID:35249568)
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Abstract
Background: Coronavirus disease 2019 (COVID-19) has disproportionately affected people with mental health conditions. Aims: We investigated the association between receiving psychotropic drugs, as an indicator of mental health conditions, and COVID-19 vaccine uptake. Method: We conducted a cross-sectional analysis of a prospective cohort of the Northern Ireland adult population using national linked primary care registration, vaccination, secondary care and pharmacy dispensing data. Univariable and multivariable logistic regression analyses investigated the association between anxiolytic, antidepressant, antipsychotic, and hypnotic use and COVID-19 vaccination status, accounting for age, gender, deprivation and comorbidities. Receiving any COVID-19 vaccine was the primary outcome. Results: There were 1 433 814 individuals, of whom 1 166 917 received a COVID-19 vaccination. Psychotropic medications were dispensed to 267 049 people. In univariable analysis, people who received any psychotropic medication had greater odds of receiving COVID-19 vaccination: odds ratio (OR) = 1.42 (95% CI 1.41–1.44). However, after adjustment, psychotropic medication use was associated with reduced odds of vaccination (ORadj = 0.90, 95% CI 0.89–0.91). People who received anxiolytics (ORadj = 0.63, 95% CI 0.61–0.65), antipsychotics (ORadj = 0.75, 95% CI 0.73–0.78) and hypnotics (ORadj = 0.90, 95% CI 0.87–0.93) had reduced odds of being vaccinated. Antidepressant use was not associated with vaccination (ORadj = 1.02, 95% CI 1.00–1.03). Conclusions: We found significantly lower odds of vaccination in people who were receiving treatment with anxiolytic and antipsychotic medications. There is an urgent need for evidence-based, tailored vaccine support for people with mental health conditions.
| Item Type: | Articles |
|---|---|
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Katikireddi, Professor Vittal |
| Authors: | Murphy, S., O'Reilly, D., Owen, R. K., Akbari, A., Lowthian, E., Bedston, S., Torabi, F., Beggs, J., Chuter, A., de Lusignan, S., Hobbs, R., Robertson, C., Katikireddi, S. V., Sheikh, A., and Bradley, D. T. |
| College/School: | College of Medical Veterinary and Life Sciences > School of Health & Wellbeing > MRC/CSO SPHSU |
| Journal Name: | British Journal of Psychiatry |
| Publisher: | Cambridge University Press |
| ISSN: | 0007-1250 |
| ISSN (Online): | 1472-1465 |
| Published Online: | 07 March 2022 |
| Copyright Holders: | Copyright © 2022 The Author(s) |
| First Published: | First published in British Journal of Psychiatry 221(1): 417-424 |
| Publisher Policy: | Reproduced under a Creative Commons licence |
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