Dennis, S.G., Wotton, P.R., Boswood, A. and Flaherty, D. (2007) Comparison of the effects of thiopentone and propofol on the electrocardiogram of dogs. Veterinary Record, 160(20), pp. 681-686. (doi: 10.1136/vr.160.20.681)
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Publisher's URL: http://dx.doi.org/10.1136/vr.160.20.681
Abstract
Sixty-four dogs were randomly assigned to receive either thiopentone or propofol and their electrocardiograms were recorded immediately before and shortly after they were anaesthetised. Thiopentone caused a marked increase in QT and JT intervals, a flattening of the T-wave and an increase in precordial QT dispersion. Propofol induced a less marked increase in QT and JT intervals, corrected for heart rate. Both agents induced an increase in heart rate and a decrease in heart rate variability, consistent with reduced vagal tone. Shortly after anaesthesia was induced, thiopentone affected ventricular repolarisation to a far greater extent than propofol, changes which suggest that it may be more likely to induce re-entrant ventricular arrhythmogenesis and could be associated with an increase in sympathetic tone. Propofol may therefore be more suitable than thiopentone for dogs with a susceptibility to ventricular arrhythmias or a long QT interval.
Item Type: | Articles |
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Status: | Published |
Refereed: | Yes |
Glasgow Author(s) Enlighten ID: | Wotton, Dr Paul and Flaherty, Professor Derek |
Authors: | Dennis, S.G., Wotton, P.R., Boswood, A., and Flaherty, D. |
College/School: | College of Medical Veterinary and Life Sciences > School of Biodiversity, One Health & Veterinary Medicine |
Journal Name: | Veterinary Record |
Publisher: | B M J Group |
ISSN: | 0042-4900 |
ISSN (Online): | 2042-7670 |
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