Small molecule based anti-virulence approaches against Candida albicans infections

Kalimuthu, S., Alshanta, O. A., Krishnamoorthy, A. L., Pudipeddi, A., Solomon, A. P., Mclean, W. , Leung, Y. Y., Ramage, G. and Neelakantan, P. (2022) Small molecule based anti-virulence approaches against Candida albicans infections. Critical Reviews in Microbiology, 48(6), pp. 743-769. (doi: 10.1080/1040841X.2021.2025337) (PMID:35232325)

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Abstract

Fungi are considered “silent killers” due to the difficulty of, and delays in diagnosis of infections and lack of effective antifungals. This challenge is compounded by the fact that being eukaryotes, fungi share several similarities with human cellular targets, creating obstacles to drug discovery. Candida albicans, a ubiquitous microbe in the human body is well-known for its role as an opportunistic pathogen in immunosuppressed people. Significantly, C. albicans is resistant to all the three classes of antifungals that are currently clinically available. Over the past few years, a paradigm shift has been recommended in the management of C. albicans infections, wherein anti-virulence strategies are considered an alternative to the discovery of new antimycotics. Small molecules, with a molecular weight <900 Daltons, can easily permeate the cell membrane and modulate the signal transduction pathways to elicit desired virulence inhibitory actions against pathogens. This review dissects in-depth, the discoveries that have been made with small-molecule anti-virulence approaches to tackle C. albicans infections.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Ramage, Professor Gordon and Mclean, Professor William and Alshanta, Ms Om Alkhir
Authors: Kalimuthu, S., Alshanta, O. A., Krishnamoorthy, A. L., Pudipeddi, A., Solomon, A. P., Mclean, W., Leung, Y. Y., Ramage, G., and Neelakantan, P.
College/School:College of Medical Veterinary and Life Sciences > School of Medicine, Dentistry & Nursing > Dental School
Journal Name:Critical Reviews in Microbiology
Publisher:Taylor & Francis
ISSN:1040-841X
ISSN (Online):1549-7828
Published Online:02 March 2022
Copyright Holders:Copyright © 2022 Informa UK Limited, trading as Taylor and Francis Group
First Published:First published in Critical Reviews in Microbiology 48(6): 743-769
Publisher Policy:Reproduced in accordance with the publisher copyright policy

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