Expression of p53 in a malignant melanoma of a goat

Hansmann, F., Herder, V. , Von Altrock, A., Dühlmeier, R. and Wohlsein, P. (2010) Expression of p53 in a malignant melanoma of a goat. Berliner und Munchener Tierarztliche Wochenschrift, 123(3-4), pp. 174-176. (doi: 10.2376/0005-9366-123-174)

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A six-year-old brown haired goat was presented due to recurring tissue growthat the base of the right horn. The tumour recurred after repeated surgical excisionand the animal was finally euthanized because of poor prognosis. Necropsyrevealed a malignant, partly amelanotic melanoma originating from the righthorn base with metastases in both frontal sinuses, urinary bladder, pleura, pericardium,second thoracic vertebra, kidney and mesenteric lymph nodes. Diagnosiswas confirmed by histopathology and immunohistochemistry. A strong expressionof p53, a suppressor of cell proliferation and activator of apoptosis, wasdetected in numerous tumour cells suggesting an altered protein function.

Item Type:Articles
Glasgow Author(s) Enlighten ID:Herder, Dr Vanessa
Authors: Hansmann, F., Herder, V., Von Altrock, A., Dühlmeier, R., and Wohlsein, P.
College/School:College of Medical Veterinary and Life Sciences > School of Infection & Immunity > Centre for Virus Research
Journal Name:Berliner und Munchener Tierarztliche Wochenschrift
Publisher:Schluetersche Verlagsgesellschaft mbH und Co. KG
ISSN (Online):1439-0299
Published Online:10 March 2010

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