Lewsey, J., Leyland, A.H., Murray, G.D., and Boddy, F.A. (2000) Using routine data to complement and enhance the results of randomised controlled trials. Health Technology Assessment, 4(22), (doi:10.3310/hta4220)
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Publisher's URL: http://dx.doi.org/10.3310/hta4220
Randomised controlled trials (RCTs) are widely accepted as the best way to assess the outcomes and safety of medical interventions, but are sometimes not ethical, not feasible, or limited in the generalisability of their results. In such circumstances, routinely available data could help in several ways. Routine data could be used, for example, to conduct ‘pseudo-trials’, to estimate likely outcomes and required sample size to help design and conduct trials, or to examine whether the expected outcomes observed in an RCT will be realised in the general population.
|Glasgow Author(s) Enlighten ID:||Leyland, Professor Alastair and Lewsey, Dr James|
|Authors:||Lewsey, J., Leyland, A.H., Murray, G.D., and Boddy, F.A.|
|Subjects:||R Medicine > R Medicine (General)|
|College/School:||College of Medical Veterinary and Life Sciences > Institute of Health and Wellbeing > MRC/CSO Unit|
College of Medical Veterinary and Life Sciences > Institute of Health and Wellbeing > Health Economics and Health Technology Assessment
College of Medical Veterinary and Life Sciences > School of Medicine, Dentistry & Nursing > Centre for Population and Health Sciences
|Journal Name:||Health Technology Assessment|