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Using routine data to complement and enhance the results of randomised controlled trials

Lewsey, J, Leyland, A.H., Murray, G.D., and Boddy, F.A. (2000) Using routine data to complement and enhance the results of randomised controlled trials. Health Technology Assessment, 4 (22). ISSN 1366-5278 (doi:10.3310/hta4220)

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Publisher's URL: http://dx.doi.org/10.3310/hta4220

Abstract

Randomised controlled trials (RCTs) are widely accepted as the best way to assess the outcomes and safety of medical interventions, but are sometimes not ethical, not feasible, or limited in the generalisability of their results. In such circumstances, routinely available data could help in several ways. Routine data could be used, for example, to conduct ‘pseudo-trials’, to estimate likely outcomes and required sample size to help design and conduct trials, or to examine whether the expected outcomes observed in an RCT will be realised in the general population.

Item Type:Article
Status:Published
Refereed:Yes
Glasgow Author(s):Leyland, Prof Alastair and Lewsey, Dr James
Authors: Lewsey, J, Leyland, A.H., Murray, G.D., and Boddy, F.A.
Subjects:R Medicine > R Medicine (General)
College/School:College of Medical Veterinary and Life Sciences > Institute of Health and Wellbeing > MRC/CSO Unit
College of Medical Veterinary and Life Sciences > School of Medicine > Centre for Population and Health Sciences
Journal Name:Health Technology Assessment
ISSN:1366-5278

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