Cuprizone inhibits demyelinating leukomyelitis by reducing immune responses without virus exacerbation in an infectious model of multiple sclerosis

Herder, V. , Hansmann, F., Stangel, M., Schaudien, D., Rohn, K., Baumgärtner, W. and Beineke, A. (2012) Cuprizone inhibits demyelinating leukomyelitis by reducing immune responses without virus exacerbation in an infectious model of multiple sclerosis. Journal of Neuroimmunology, 244(1-2), pp. 84-93. (doi: 10.1016/j.jneuroim.2012.01.010) (PMID:22329906)

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Abstract

Multiple sclerosis is one of the most common demyelinating central nervous system diseases in young adults. Theiler's murine encephalomyelitis (TME) is a widely used virus-induced murine model for human myelin disorders. Immunosuppressive approaches generally reduce antiviral immunity and therefore increase virus dissemination with clinical worsening. In the present study, the progressive course of TME was significantly delayed due to a five-week cuprizone feeding period. Cuprizone was able to minimize demyelinating leukomyelitis without virus exacerbation. This phenomenon is supposed to be a consequence of selective inhibition of detrimental inflammatory responses with maintained protective immunity against the virus.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Herder, Dr Vanessa
Authors: Herder, V., Hansmann, F., Stangel, M., Schaudien, D., Rohn, K., Baumgärtner, W., and Beineke, A.
College/School:College of Medical Veterinary and Life Sciences > School of Infection & Immunity > Centre for Virus Research
Journal Name:Journal of Neuroimmunology
Publisher:Elsevier
ISSN:0165-5728
ISSN (Online):1872-8421
Published Online:11 February 2012

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