Associations between dietary patterns, FTO genotype and obesity in adults from seven European countries

Livingstone, K. M. et al. (2022) Associations between dietary patterns, FTO genotype and obesity in adults from seven European countries. European Journal of Nutrition, (doi: 10.1007/s00394-022-02858-3) (PMID:35307761) (Early Online Publication)

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Abstract

Purpose High-fat and low-fibre discretionary food intake and FTO genotype are each associated independently with higher risk of obesity. However, few studies have investigated links between obesity and dietary patterns based on discretionary food intake, and the interaction effect of FTO genotype are unknown. Thus, this study aimed to derive dietary patterns based on intake of discretionary foods, saturated fatty acids (SFA) and fibre, and examine cross-sectional associations with BMI and waist circumference (WC), and interaction effects of FTO genotype. Methods Baseline data on 1280 adults from seven European countries were included (the Food4Me study). Dietary intake was estimated from a Food Frequency Questionnaire. Reduced rank regression was used to derive three dietary patterns using response variables of discretionary foods, SFA and fibre density. DNA was extracted from buccal swabs. Anthropometrics were self-measured. Linear regression analyses were used to examine associations between dietary patterns and BMI and WC, with an interaction for FTO genotype. Results Dietary pattern 1 (positively correlated with discretionary foods and SFA, and inversely correlated with fibre) was associated with higher BMI (β:0.64; 95% CI 0.44, 0.84) and WC (β:1.58; 95% CI 1.08, 2.07). There was limited evidence dietary pattern 2 (positively correlated with discretionary foods and SFA) and dietary pattern 3 (positively correlated with SFA and fibre) were associated with anthropometrics. FTO risk genotype was associated with higher BMI and WC, with no evidence of a dietary interaction. Conclusions Consuming a dietary pattern low in discretionary foods and high-SFA and low-fibre foods is likely to be important for maintaining a healthy weight, regardless of FTO predisposition to obesity.

Item Type:Articles
Status:Early Online Publication
Refereed:Yes
Glasgow Author(s) Enlighten ID:Celis, Dr Carlos
Authors: Livingstone, K. M., Brayner, B., Celis-Morales, C., Moschonis, G., Manios, Y., Traczyk, I., Drevon, C. A., Daniel, H., Saris, W. H. M., Lovegrove, J. A., Gibney, M., Gibney, E. R., Brennan, L., Martinez, J. A., and Mathers, J. C.
College/School:College of Medical Veterinary and Life Sciences > Institute of Cardiovascular and Medical Sciences
Journal Name:European Journal of Nutrition
Publisher:Springer
ISSN:1436-6207
ISSN (Online):1436-6215
Published Online:21 March 2022
Copyright Holders:Copyright © The Author(s) 2022
First Published:First published in European Journal of Nutrition 2022
Publisher Policy:Reproduced under a Creative Commons licence

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