The impact of compliance during exclusive enteral nutrition on faecal calprotectin in children with Crohn’s disease

Mckirdy, S., Russell, R. K., Svolos, V., Gkikas, K. , Logan, M. , Hansen, R. and Gerasimidis, K. (2022) The impact of compliance during exclusive enteral nutrition on faecal calprotectin in children with Crohn’s disease. Journal of Pediatric Gastroenterology and Nutrition, 74(6), pp. 801-804. (doi: 10.1097/MPG.0000000000003425) (PMID:35192573)

Abstract

It remains unclear whether suboptimal response to exclusive enteral nutrition (EEN) in some children with Crohn's disease (CD) is explained by poor compliance. The current study measured faecal gluten immunogenic peptides (GIP), a biomarker of gluten intake, in 45 children (3–17 years) with CD, and explored associations with faecal calprotectin (FC) levels at 33 and 54 days of EEN. FC decreased in patients with undetectable GIP at both 33 and 54 days of EEN (mean decrease, 33 days: -743 mg/kg, 54 days: -1043 mg/kg, p < 0.001), but not in patients who had detectable levels. At EEN completion, patients with undetectable GIP had a lower FC by 717 mg/kg compared with patients with a positive GIP result (p = 0.042) and demonstrated a greater decline from baseline FC (-69% vs +5%, p = 0.011). Poorer response to EEN is explained in part by diminished compliance. Faecal GIP might be useful as proxy biomarker of EEN compliance.

• Item Type: Articles
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Hansen, Dr Richard and Gkikas, Dr Konstantinos and Logan, Dr Michael and Russell, Dr Richard and Mckirdy, Miss Shona and Gerasimidis, Professor Konstantinos and Svolos, Dr Vaios
• Authors: Mckirdy, S., Russell, R. K., Svolos, V., Gkikas, K., Logan, M., Hansen, R., and Gerasimidis, K.
• College/School: College of Medical Veterinary and Life Sciences > School of Medicine, Dentistry & Nursing
• Journal Name: Journal of Pediatric Gastroenterology and Nutrition
• Publisher: Lippincott, Williams & Wilkins
• ISSN: 0277-2116
• ISSN (Online): 1536-4801
• Published Online: 22 February 2022
• Copyright Holders: Copyright © 2022 European Society for Pediatric Gastroenterology, Hepatology, and Nutrition and North American Society for Pediatric Gastroenterology
• First Published: First published in Journal of Pediatric Gastroenterology and Nutrition 74(6): 801-804
• Publisher Policy: Reproduced in accordance with the publisher copyright policy