Lee, K., Dixon, A. K., Rowe, I. C.M. , Ashford, M. L. J. and Richardson, P. J. (1995) Direct demonstration of sulphonylurea-sensitive KATP channels on nerve terminals of the rat motor cortex. British Journal of Pharmacology, 115(3), pp. 385-388. (doi: 10.1111/j.1476-5381.1995.tb16344.x) (PMID:7582446) (PMCID:PMC1908424)
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Abstract
We examined whether ATP-sensitive potassium (KATP) channels are present on presynaptic terminals of the rat motor cortex, an area of the CNS exhibiting a high density of sulphonylurea binding. A novel fused nerve terminal preparation was developed which produced structures amenable to patch clamp methods. In inside-out recordings a K+channel was observed which possessed all the major features of the Type 1 KATP channel, including sensitivity to ATP and the antidiabetic sulphonylureas.
| Item Type: | Articles |
|---|---|
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Rowe, Dr Iain |
| Authors: | Lee, K., Dixon, A. K., Rowe, I. C.M., Ashford, M. L. J., and Richardson, P. J. |
| College/School: | College of Medical Veterinary and Life Sciences > School of Life Sciences |
| Journal Name: | British Journal of Pharmacology |
| Publisher: | Stockton Press |
| ISSN: | 0007-1188 |
| ISSN (Online): | 1476-5381 |
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