Effects of dispersed fibres in myocardial mechanics, Part II: active response

Guan, D., Wang, Y., Xu, L., Cai, L., Luo, X. and Gao, H. (2022) Effects of dispersed fibres in myocardial mechanics, Part II: active response. Mathematical Biosciences and Engineering, 19(4), pp. 4101-4119. (doi: 10.3934/mbe.2022189)

Abstract

This work accompanies the first part of our study "effects of dispersed fibres in myocardial mechanics: Part I passive response" with a focus on myocardial active contraction. Existing studies have suggested that myofibre architecture plays an important role in myocardial active contraction. Following the first part of our study, we firstly study how the general fibre architecture affects ventricular pump function by varying the mean myofibre rotation angles, and then the impact of fibre dispersion along the myofibre direction on myocardial contraction in a left ventricle model. Dispersed active stress is described by a generalised structure tensor method for its computational efficiency. Our results show that both the myofibre rotation angle and its dispersion can significantly affect cardiac pump function by redistributing active tension circumferentially and longitudinally. For example, larger myofibre rotation angle and higher active tension along the sheet-normal direction can lead to much reduced end-systolic volume and higher longitudinal shortening, and thus a larger ejection fraction. In summary, these two studies together have demonstrated that it is necessary and essential to include realistic fibre structures (both fibre rotation angle and fibre dispersion) in personalised cardiac modelling for accurate myocardial dynamics prediction.

• Item Type: Articles
• Additional Information: We are grateful for the funding provided by the UK EPSRC (EP/S030875, EP/S020950/1, EP/S014284/1, EP/R511705/1 ) and H.G. further acknowledges the EPSRC ECR Capital Award (308011). L.C acknowledges the National Natural Science Foundation of China (11871399, 11471261, 11571275). D.G. also acknowledges funding from the Chinese Scholarship Council and the fee waiver from the University of Glasgow.
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Luo, Professor Xiaoyu and Guan, Mr Debao and Gao, Dr Hao and Cai, Dr Li and Wang, Yingjie
• Authors: Guan, D., Wang, Y., Xu, L., Cai, L., Luo, X., and Gao, H.
• College/School: College of Science and Engineering > School of Mathematics and Statistics; College of Science and Engineering > School of Mathematics and Statistics > Mathematics
• Journal Name: Mathematical Biosciences and Engineering
• Publisher: American Institute of Mathematical Sciences
• ISSN: 1547-1063
• ISSN (Online): 1551-0018
• Published Online: 16 February 2022
• Copyright Holders: Copyright © 2022 The Authors
• First Published: First published in Mathematical Biosciences and Engineering 19(4): 4101-4119
• Publisher Policy: Reproduced under a Creative Commons licence

Project Code	Award No	Project Name	Principal Investigator	Funder's Name	Funder Ref	Lead Dept
303232		EPSRC Centre for Multiscale soft tissue mechanics with MIT and POLIMI (SofTMech-MP)	Xiaoyu Luo	Engineering and Physical Sciences Research Council (EPSRC)	EP/S030875/1	M&S - Mathematics
303231		A whole-heart model of multiscale soft tissue mechanics and fluid structureinteraction for clinical applications (Whole-Heart-FSI)	Xiaoyu Luo	Engineering and Physical Sciences Research Council (EPSRC)	EP/S020950/1	M&S - Mathematics
303798		Growth and Remodelling in Neoanatal Porcine Heart-- Pushing Mathematics through Experiments	Xiaoyu Luo	Engineering and Physical Sciences Research Council (EPSRC)	EP/S014284/1	M&S - Mathematics
304896		EPSRC-IAA: Early Stage Commercialisation of a PET Imaging Agent for the Detection of Cardiovascular Disease and Cancer	Andrew Sutherland	Engineering and Physical Sciences Research Council (EPSRC)	EP/R511705/1	Chemistry