Annexin-A1: the culprit or the solution?

Kelly, L., McGrath, S., Rodgers, L., McCall, K., Tulunay Virlan, A. , Dempsey, F., Crichton, S. and Goodyear, C. S. (2022) Annexin-A1: the culprit or the solution? Immunology, 166(1), pp. 2-16. (doi: 10.1111/imm.13455) (PMID:35146757)

Abstract

Annexin-A1 has a well-defined anti-inflammatory role in the innate immune system, but its function in adaptive immunity remains controversial. This glucocorticoid-induced protein has been implicated in a range of inflammatory conditions and cancers, as well as being found to be overexpressed on the T cells of patients with autoimmune disease. Moreover, the formyl peptide family of receptors, through which annexin-A1 primarily signals, have also been implicated in these diseases. In contrast, treatment with recombinant annexin-A1 peptides resulted in suppression of inflammatory processes in murine models of inflammation. This review will focus on what is currently known about annexin-A1 in heath and disease and discuss the potential of this protein as a biomarker and therapeutic target.

• Item Type: Articles
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: McCall, Kathryn and Tulunay Virlan, Dr Aysin and Kelly, Lauren and McGrath, Sarah and Goodyear, Professor Carl and Rodgers, Mr Lewis
• Authors: Kelly, L., McGrath, S., Rodgers, L., McCall, K., Tulunay Virlan, A., Dempsey, F., Crichton, S., and Goodyear, C. S.
• College/School: College of Medical Veterinary and Life Sciences > School of Infection & Immunity
• Research Centre: College of Medical Veterinary and Life Sciences > School of Infection & Immunity > Centre for Immunobiology
• Journal Name: Immunology
• Publisher: Wiley
• ISSN: 0019-2805
• ISSN (Online): 1365-2567
• Published Online: 10 February 2022
• Copyright Holders: Copyright © 2022 The Authors
• First Published: First published in Immunology 166(1): 2-16
• Publisher Policy: Reproduced under a Creative Commons License

Project Code	Award No	Project Name	Principal Investigator	Funder's Name	Funder Ref	Lead Dept
301182		Annexin-A1 as a target for T cell mediated pathology in Psoriatic arthritis	Carl Goodyear	Medical Research Scotland (MEDRESSC)	PhD-1163-2017	III - Immunology