Systematic review: association between circulating microRNA expression & stroke

Fullerton, J. L., Thomas, J. M., Gonzalez-Trueba, L., Trivett, C., Van Kralingen, J. C., Allan, S. M., Quinn, T. J. and Work, L. M. (2022) Systematic review: association between circulating microRNA expression & stroke. Journal of Cerebral Blood Flow and Metabolism, 42(6), pp. 935-951. (doi: 10.1177/0271678X221085090) (PMID:35240874)

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Abstract

This systematic review aimed to establish the range and quality of clinical and preclinical evidence supporting the association of individual microRNAs, and the use of microRNA expression in the diagnosis and prognosis of ischaemic or haemorrhagic stroke. Electronic databases were searched from 1993 to October 2021, using key words relevant to concepts of stroke and microRNA. Studies that met specific inclusion and exclusion criteria were selected for data extraction. To minimise erroneous associations, findings were restricted to microRNAs reported to change in more than two independent studies. Of the papers assessed, 155 papers reported a change in microRNA expression observed in more than two independent studies. In ischaemic studies, two microRNAs were consistently differentially expressed in clinical samples (miR-29b & miR-146a) and four were altered in preclinical samples (miR-137, miR-146a, miR-181b & miR-223-3p). Across clinical and preclinical haemorrhagic studies, four microRNAs were downregulated consistently (miR-26a, miR-126, miR-146a & miR-155). Across included studies, miR-126 and miR-146a were the only two microRNAs to be differentially expressed in clinical and preclinical cohorts following ischaemic or haemorrhagic stroke. Further studies, employing larger populations with consistent methodologies, are required to validate the true clinical value of circulating microRNAs as biomarkers of ischaemic and haemorrhagic stroke.

Item Type:Articles
Additional Information:The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: this work was supported by the Chief Scientific Office [Project grant TCS/18/13] (TJQ & LMW), the British Heart Foundation (BHF) 4 Year PhD Studentship Awards FS/19/ 56/34893 (CT) and FS/4yPhD/F/20/34127 (LGT) and by an Engineering and Physical Science Research Council (EPSRC, UK) and Medical Research Council (MRC, UK) Centre for Doctoral Training in Regenerative Medicine Studentship Grant [No. EP/L014904/1] (JMT).
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Trivett, Miss Cara and Work, Dr Lorraine and Van Kralingen, Ms Josie and Quinn, Dr Terry and Fullerton, Dr Josie
Authors: Fullerton, J. L., Thomas, J. M., Gonzalez-Trueba, L., Trivett, C., Van Kralingen, J. C., Allan, S. M., Quinn, T. J., and Work, L. M.
College/School:College of Medical Veterinary and Life Sciences > School of Cardiovascular & Metabolic Health
Journal Name:Journal of Cerebral Blood Flow and Metabolism
Publisher:SAGE Publications
ISSN:0271-678X
ISSN (Online):1559-7016
Published Online:03 March 2022
Copyright Holders:Copyright © 2022 The Authors
First Published:First published in Journal of Cerebral Blood Flow and Metabolism 42(6): 935-951
Publisher Policy:Reproduced under a Creative Commons License

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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
303006Extracellular vesicle mediated microRNA delivery as a therapeutic for ischaemic strokeLorraine WorkOffice of the Chief Scientific Adviser (CSO)TCS/18/13CAMS - Cardiovascular Science
309321BHF 4Yr PhD Studentship Award 2109Rhian TouyzBritish Heart Foundation (BHF)FS/19/56/34893CAMS - Cardiovascular Science
311102BHF 4Yr PhD Studentship Award 2020Rhian TouyzBritish Heart Foundation (BHF)FS/4yPhD/F/20/34127CAMS - Cardiovascular Science