Krenn, V. et al. (2017) 15 Jahre histopathologischer Synovialitis-Score = Fifteen years of the histopathological synovitis score: review and further developments of a diagnostic score. Zeitschrift fur Rheumatologie, 76(6), pp. 539-546. (doi: 10.1007/s00393-017-0308-2) (PMID:28470440)
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Abstract
The histopathological synovitis score evaluates in a graded approach, as is largely usual for diagnostic histopathological scores, the immunological and inflammatory changes caused by synovitis. A synovitis score of between 1 and ≤ 4 is classified as low-grade (osteoarthritis-related synovitis, post-traumatic synovitis, meniscopathy-related synovitis and synovitis in hemochromatosis). Synovitis scores of between ≥ 5 and 9 are classified as high-grade synovitis (rheumatoid arthritis, psoriatic arthritis, Lyme’s arthritis, post-infection/reactive arthritis and peripheral arthritis in Bechterew disease); sensitivity is 61.7% and sensitivity 96.1%. According to receiver operating characteristic (ROC) analysis (AUC: 0.8–0.9), diagnostic value is good. National and international acceptance of the synovitis score has grown since the first publication in 2002 and a related follow-up publication in 2006. PubMed data analysis (as of 11.01.2017) yielded the following citation values according to “cited by PubMed Central articles” for two publications relating to the synovitis score: there were 29 cited-by-PubMed articles for DOI: 10.1078/0344-0338-5710261, and 44 cited-in-PubMed articles for the second publication, DOI: 10.1111/j.1365-2559.2006.02508. This makes a total of 73 PubMed citations over a period of 15 years, thereby evidencing the score’s international acceptance. Immunohistochemical determination of a number of CD antigens relevant to inflammation has been proposed to further specify the synovitis score for the purposes of risk stratification of high-grade synovitis (e.g., risk of progression and sensitivity to biological agents).
| Item Type: | Articles |
|---|---|
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Najm, Dr Aurelie |
| Authors: | Krenn, V., Perino, G., Rüther, W., Krenn, V. T., Huber, M., Hügle, T., Najm, A., Müller, S., Boettner, F., Pessler, F., Waldstein, W., Kriegsmann, J., Häupl, T., Wienert, S., Krukemeyer, M. G., Sesselmann, S., Tikhilov, R., and Morawietz, L. |
| College/School: | College of Medical Veterinary and Life Sciences > School of Infection & Immunity |
| Journal Name: | Zeitschrift fur Rheumatologie |
| Publisher: | Springer |
| ISSN: | 0340-1855 |
| ISSN (Online): | 1435-1250 |
| Published Online: | 03 May 2017 |
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