Coronary arterial function and disease in women with no obstructive coronary arteries

Reynolds, H. R., Bairey Merz, C. N., Berry, C. , Samuel, R., Saw, J., Smilowitz, N. R., de Souza, A. C. d. A.H., Sykes, R. , Taqueti, V. R. and Wei, J. (2022) Coronary arterial function and disease in women with no obstructive coronary arteries. Circulation Research, 130(4), pp. 529-551. (doi: 10.1161/CIRCRESAHA.121.319892) (PMID:35175840) (PMCID:PMC8911308)

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Abstract

Ischemic heart disease (IHD) is the leading cause of mortality in women. While traditional cardiovascular risk factors play an important role in the development of IHD in women, women may experience sex-specific IHD risk factors and pathophysiology, and thus female-specific risk stratification is needed for IHD prevention, diagnosis, and treatment. Emerging data from the past 2 decades have significantly improved the understanding of IHD in women, including mechanisms of ischemia with no obstructive coronary arteries and myocardial infarction with no obstructive coronary arteries. Despite this progress, sex differences in IHD outcomes persist, particularly in young women. This review highlights the contemporary understanding of coronary arterial function and disease in women with no obstructive coronary arteries, including coronary anatomy and physiology, mechanisms of ischemia with no obstructive coronary arteries and myocardial infarction with no obstructive coronary arteries, noninvasive and invasive diagnostic strategies, and management of IHD.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Berry, Professor Colin and Sykes, Dr Robert
Authors: Reynolds, H. R., Bairey Merz, C. N., Berry, C., Samuel, R., Saw, J., Smilowitz, N. R., de Souza, A. C. d. A.H., Sykes, R., Taqueti, V. R., and Wei, J.
College/School:College of Medical Veterinary and Life Sciences > School of Cardiovascular & Metabolic Health
Journal Name:Circulation Research
Publisher:American Heart Association
ISSN:0009-7330
ISSN (Online):1524-4571
Published Online:17 February 2022
Copyright Holders:Copyright © 2022 American Heart Association, Inc.
First Published:First published in Circulation Research 130(4): 529-551
Publisher Policy:Reproduced in accordance with the publisher copyright policy

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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
174109The conundrum of angina in patients without obstructive coronary disease: a randomised controlled pilot trial of routine testing of coronary function.Colin BerryBritish Heart Foundation (BHF)FS/17/26/32744Institute of Cardiovascular & Medical Sciences
303161The BHF FAMOUS-NSTEMI long-term follow-up studyColin BerryBritish Heart Foundation (BHF)PG/18/52/33892CAMS - Cardiovascular Science
303944BHF Centre of ExcellenceColin BerryBritish Heart Foundation (BHF)RE/18/6/34217CAMS - Cardiovascular Science
303684A randomized, double-blind, placebo-controlled Phase 2A cross-over trial of oral zibotentan in patients with angina due to small vessel disease: a proof-of-concept, developmental trial for safety, efficacy and biomarkers developmentColin BerryMedical Research Council (MRC)MR/S018905/1CAMS - Cardiovascular Science