Najm, A. and McInnes, I. B. (2021) IL-23 orchestrating immune cell activation in arthritis. Rheumatology, 60(Suppl4), iv4-iv15. (doi: 10.1093/rheumatology/keab266) (PMID:34668017) (PMCID:PMC8527242)
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Abstract
IL-23 is a cytokine member of the IL-12 superfamily. These heterodimeric cytokines offer broad immune regulatory activity with potential effector function in inflammatory arthritis. IL-23 is a pro-inflammatory cytokine secreted by dendritic cells and macrophages. It plays a key role in both innate and adaptive immunity. By promoting and maintaining T cell differentiation into Th17 T cells, IL-23 is a key player in the pathogenesis of rheumatic diseases. Data from pre-clinical IL-23 knockout models show the major importance of IL-23 in development of arthritis. The induction and maintenance of type 17 cells, which secrete IL-17A and other pro-inflammatory cytokines, contributes to local synovial inflammation and skin inflammation in PsA, and perhaps in RA. Commensurate with this, therapeutic strategies targeting IL-23 have proven efficient in PsA in several studies, albeit not yet in RA.
| Item Type: | Articles |
|---|---|
| Additional Information: | Funding: This project was funded by the PARTNER Fellowship Program. This paper was published as part of a supplement sponsored by the Janssen Pharmaceutical Companies of Johnson & Johnson. |
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | McInnes, Professor Iain and Najm, Dr Aurelie |
| Authors: | Najm, A., and McInnes, I. B. |
| College/School: | College of Medical Veterinary and Life Sciences > School of Infection & Immunity College of Medical Veterinary and Life Sciences > School of Medicine, Dentistry & Nursing |
| Research Centre: | College of Medical Veterinary and Life Sciences > School of Infection & Immunity > Centre for Immunobiology |
| Journal Name: | Rheumatology |
| Publisher: | Oxford University Press |
| ISSN: | 1462-0324 |
| ISSN (Online): | 1462-0332 |
| Published Online: | 20 October 2021 |
| Copyright Holders: | Copyright © The Author(s) 2021 |
| First Published: | First published in Rheumatology 60(Suppl4): iv4-iv15 |
| Publisher Policy: | Reproduced under a Creative Commons licence |
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