Bell, S. et al. (2022) The impact of vaccination on incidence and outcomes of SARS-CoV-2 infection in patients with kidney failure in Scotland. Journal of the American Society of Nephrology, 33(4), pp. 677-686. (doi: 10.1681/ASN.2022010046) (PMID:35110363)
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Abstract
Background: Patients with kidney failure requiring kidney replacement therapy (KRT) are at high risk of complications and death following SARS-CoV-2 infection with variable antibody responses to vaccination reported. We investigated the effects of COVID-19 vaccination on incidence of infection, hospitalization and death of COVID-19 infection. Methods: Study design was an observational data linkage cohort study. Multiple healthcare datasets were linked to ascertain all SARS-CoV-2 testing, vaccination, hospitalization, and mortality data for all patients treated with KRT in Scotland, from the start of the pandemic over a period of 20 months. Descriptive statistics, survival analyses, and vaccine effectiveness were calculated. Results: As of 19th September 2021, 93% (n=5281) of the established KRT population in Scotland had received two doses of an approved SARS-CoV-2 vaccine. Over the study period, there were 814 cases of SARS-CoV-2 infection (15.1% of the KRT population). Vaccine effectiveness against infection and hospitalization was 33% (95% CI 0-52) and 38% (95% CI 0-57) respectively. 9.2% of fully vaccinated individuals died within 28 days of a SARS-CoV-2 positive PCR test (7% dialysis patients and 10% kidney transplant recipients). This compares to <0.1% of the vaccinated Scottish population being admitted to hospital or dying death due to COVID19 during that period. Conclusions: These data demonstrate a primary vaccine course of two doses has limited impact on COVID-19 infection and its complications in patients treated with KRT. Adjunctive strategies to reduce risk of both COVID-19 infection and its complications in this population are urgently required.
Item Type: | Articles |
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Status: | Published |
Refereed: | Yes |
Glasgow Author(s) Enlighten ID: | Findlay, Dr Mark and Methven, Dr Shona and Spalding, Dr Elaine and Thomson, Dr Peter and Mark, Professor Patrick and Traynor, Dr Jamie and Joss, Dr Nicola |
Authors: | Bell, S., Campbell, J., Lambourg, E., Watters, C., O’Neil, M., Almond, A., Buck, K., Carr, E. J., Clark, L., Cousland, Z., Findlay, M., Joss, N., Metcalfe, W., Petrie, M., Spalding, E., Traynor, J. P., Sanu, V., Thomson, P., Methven, S., and Mark, P. B. |
College/School: | College of Medical Veterinary and Life Sciences > School of Cardiovascular & Metabolic Health College of Medical Veterinary and Life Sciences > School of Medicine, Dentistry & Nursing |
Journal Name: | Journal of the American Society of Nephrology |
Publisher: | American Society of Nephrology |
ISSN: | 1046-6673 |
ISSN (Online): | 1533-3450 |
Published Online: | 02 February 2022 |
Copyright Holders: | Copyright © ASN 2022 |
First Published: | First published in Journal of the American Society of Nephrology 33(4): 677-686 |
Publisher Policy: | Reproduced in accordance with the publisher copyright policy |
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