Oligodendroglial modulation of fast axonal transport in a mouse model of hereditary spastic paraplegia

Edgar, J. et al. (2004) Oligodendroglial modulation of fast axonal transport in a mouse model of hereditary spastic paraplegia. Journal of Cell Biology, 166(1), pp. 121-131. (doi:10.1083/jcb.200312012) (PMID:15226307) (PMCID:PMC2172145)

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Abstract

Oligodendrocytes are critical for the development of the plasma membrane and cytoskeleton of the axon. In this paper, we show that fast axonal transport is also dependent on the oligodendrocyte. Using a mouse model of hereditary spastic paraplegia type 2 due to a null mutation of the myelin Plp gene, we find a progressive impairment in fast retrograde and anterograde transport. Increased levels of retrograde motor protein subunits are associated with accumulation of membranous organelles distal to nodal complexes. Using cell transplantation, we show categorically that the axonal phenotype is related to the presence of the overlying Plp null myelin. Our data demonstrate a novel role for oligodendrocytes in the local regulation of axonal function and have implications for the axonal loss associated with secondary progressive multiple sclerosis.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:McLaughlin, Dr Mark and Edgar, Dr Julia and Griffiths, Prof Ian and Yool, Professor Donald
Authors: Edgar, J., McLaughlin, M., Yool, D., Zhang, S., Fowler, J., Montague, P., Barrie, J., McCulloch, M., Duncan, I., Garbern, J., Nave, K., and Griffiths, I.
College/School:College of Medical Veterinary and Life Sciences > Institute of Infection Immunity and Inflammation
College of Medical Veterinary and Life Sciences > School of Veterinary Medicine
Journal Name:Journal of Cell Biology
Publisher:Rockefeller University Press
ISSN:0021-9525
ISSN (Online):1540-8140
Published Online:28 June 2004

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