Lymphatic Vascular Regeneration: The Next Step in Tissue Engineering

Huethorst, E. , Krebber, M. M., Fledderus, J. O., Gremmels, H., Xu, Y. J., Pei, J., Verhaar, M. C. and Cheng, C. (2016) Lymphatic Vascular Regeneration: The Next Step in Tissue Engineering. Tissue Engineering Part B: Reviews, 22(1), pp. 1-14. (doi: 10.1089/ten.teb.2015.0231) (PMID:26204330)

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Abstract

The lymphatic system plays a crucial role in interstitial fluid drainage, lipid absorption, and immunological defense. Lymphatic dysfunction results in lymphedema, fluid accumulation, and swelling of soft tissues, as well as a potentially impaired immune response. Lymphedema significantly reduces quality of life of patients on a physical, mental, social, and economic basis. Current therapeutic approaches in treatment of lymphatic disease are limited. Over the last decades, great progress has been made in the development of therapeutic strategies to enhance vascular regeneration. These solutions to treat vascular disease may also be applicable in the treatment of lymphatic diseases. Comparison of the organogenic process and biological organization of the vascular and lymphatic systems and studies in the regulatory mechanisms involved in lymphangiogenesis and angiogenesis show many common features. In this study, we address the similarities between both transport systems, and focus in depth on the biology of lymphatic development. Based on the current advances in vascular regeneration, we propose different strategies for lymphatic tissue engineering that may be used for treatment of primary and secondary lymphedema.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Huethorst, Miss Eline
Authors: Huethorst, E., Krebber, M. M., Fledderus, J. O., Gremmels, H., Xu, Y. J., Pei, J., Verhaar, M. C., and Cheng, C.
College/School:College of Medical Veterinary and Life Sciences > School of Cardiovascular & Metabolic Health
Journal Name:Tissue Engineering Part B: Reviews
Publisher:Mary Ann Liebert Inc
ISSN:2152-4947
ISSN (Online):2152-4955
Published Online:18 November 2015

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