Electrofabrication of large volume di- and tripeptide hydrogels via hydroquinone oxidation

Patterson, C., Dietrich, B. , Wilson, C. , Mount, A. R. and Adams, D. J. (2022) Electrofabrication of large volume di- and tripeptide hydrogels via hydroquinone oxidation. Soft Matter, 18(5), pp. 1064-1070. (doi: 10.1039/D1SM01626A) (PMID:35022641)

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Abstract

The fabrication of protected peptide-based hydrogels on electrode surfaces can be achieved by employing the electrochemical oxidation of hydroquinone to benzoquinone, liberating protons at the electrode-solution interface. The localised reduction in pH below the dipeptide gelator molecules pKa initiates the neutralisation, self-assembly and formation of self-supporting hydrogels exclusively at the electrode surface. Previous examples have been on a nanometre to millimetre scale, using deposition times ranging from seconds to minutes. However, the maximum size to which these materials can grow and their subsequent mechanical properties have not yet been investigated. Here, we report the fabrication of the largest reported di- and tri-peptide based hydrogels using this electrochemical method, employing deposition times of two to five hours. To overcome the oxidation of hydroquinone in air, the fabrication process was performed under an inert nitrogen atmosphere. We show that this approach can be used to form multilayer gels, with the mechanical properties of each layer determined by gelator composition. We also describe examples were gel-to-crystal transitions and syneresis occurs within the material.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Dietrich, Bart and Adams, Dave and Patterson, Miss Courtenay and Wilson, Dr Claire
Creator Roles:
Patterson, C.Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Writing – original draft, Writing – review and editing
Dietrich, B.Data curation, Investigation, Methodology, Writing – original draft, Writing – review and editing
Wilson, C.Data curation, Formal analysis, Investigation, Methodology, Writing – original draft, Writing – review and editing
Adams, D. J.Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Supervision, Writing – original draft, Writing – review and editing
Authors: Patterson, C., Dietrich, B., Wilson, C., Mount, A. R., and Adams, D. J.
College/School:College of Science and Engineering > School of Chemistry
Journal Name:Soft Matter
Publisher:Royal Society of Chemistry
ISSN:1744-683X
ISSN (Online):1744-6848
Published Online:03 January 2022
Copyright Holders:Copyright © 2022 The Royal Society of Chemistry
First Published:First published in Soft Matter 18(5): 1064-1070
Publisher Policy:Reproduced in accordance with the publisher copyright policy

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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
305912Spatially- and temporally-controlled photothermal GelsDave AdamsLeverhulme Trust (LEVERHUL)RPG-2019-165Chemistry