Plasma endothelinlike immunoreactivity levels in IDDM patients with microalbuminuria

Collier, A., Leach, J. P. , McLelland, A., Jardine, A. , Morton, J. J. and Small, M. (1992) Plasma endothelinlike immunoreactivity levels in IDDM patients with microalbuminuria. Diabetes Care, 15(8), pp. 1038-1040. (doi: 10.2337/diacare.15.8.1038) (PMID:1505306)

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Abstract

Objective: To determine whether plasma endothelin, a potent vasoconstrictor and growth factor for vascular smooth muscle, is elevated in microalbuminuric insulin-dependent diabetes mellitus patients. Research Design and Methods: Plasma endothelinlike immunoreactivity was measured by radioimmunoassay in 15 microalbuminuric diabetic patients, 12 normoalbuminuric diabetic patients, and 12 control subjects. Results: The mean levels of plasma endothelinlike immunoreactivity were raised in the normoalbuminuric patients (8.4 pM [range 4.8–12.7 pM]; P < 0.01) and the microalbuminuric patients (10.2 pM [range 5.6–31.1 pM]; P < 0.001) compared with control subjects (6.1 pM [range 4.5–7.6 pM]). Plasma endothelinlike immunoreactivity was also higher in the microalbuminuric patients compared with the normoalbuminuric patients (P < 0.05). Conclusions: The increase in plasma endothelinlike immunoreactivity further confirms endothelial dysfunction in diabetes and this increase in plasma endothelin may contribute to the vascular disease prevalent in diabetes.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Leach, Dr John Paul and Morton, Dr James and Jardine, Professor Alan
Authors: Collier, A., Leach, J. P., McLelland, A., Jardine, A., Morton, J. J., and Small, M.
College/School:College of Medical Veterinary and Life Sciences > School of Medicine, Dentistry & Nursing
Journal Name:Diabetes Care
Publisher:American Diabetes Association
ISSN:0149-5992
ISSN (Online):1935-5548

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