Leschziner, G. D., Andrew, T., Leach, J. P. , Chadwick, D., Coffey, A. J., Balding, D. J., Bentley, D. R., Pirmohamed, M. and Johnson, M. R. (2007) Common ABCB1 polymorphisms are not associated with multidrug resistance in epilepsy using a gene-wide tagging approach. Pharmacogenetics and Genomics, 17(3), pp. 217-230. (doi: 10.1097/01.fpc.0000230408.23146.b1) (PMID:17460550)
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Abstract
P-glycoprotein, the product of the ABCB1 gene, is a proposed mechanism of pharmacoresistance in epilepsy. Previous attempts to correlate the ABCB1 C3435T SNP, or a three-SNP haplotype containing C3435T with epilepsy pharmacoresistance have produced discordant findings. We analysed these single nucleotide polymorphisms (SNPs), plus a more comprehensive set of tagging SNPs describing common variation in ABCB1 in a case–control study. No significant association of C3435T (P=0.55), the three-SNP haplotype (lowest P=0.14) or any gene-wide tagging SNP (lowest P=0.17) with multidrug resistance in epilepsy was identified. Meta-analysis of studies using the same definition of multidrug resistance (n=1064) also demonstrated no significant association of C3435T with multidrug resistance (P=0.31). These findings suggest that C3435T is unlikely to be a marker for epilepsy multidrug resistance. In addition, no evidence for a role of other common ABCB1 polymorphisms was found using a potentially more powerful gene-wide tagging approach.
| Item Type: | Articles |
|---|---|
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Leach, Dr John Paul |
| Authors: | Leschziner, G. D., Andrew, T., Leach, J. P., Chadwick, D., Coffey, A. J., Balding, D. J., Bentley, D. R., Pirmohamed, M., and Johnson, M. R. |
| College/School: | College of Medical Veterinary and Life Sciences > School of Medicine, Dentistry & Nursing |
| Journal Name: | Pharmacogenetics and Genomics |
| Publisher: | Lippincott Williams & Wilkins |
| ISSN: | 1744-6872 |
| ISSN (Online): | 1744-6880 |
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