Ultra-thin chips with ISFET array for continuous monitoring of body fluids pH

Shojaei Baghini, M. , Vilouras, A. and Dahiya, R. (2021) Ultra-thin chips with ISFET array for continuous monitoring of body fluids pH. IEEE Transactions on Biomedical Circuits and Systems, 15(6), pp. 1174-1185. (doi: 10.1109/TBCAS.2022.3141553)

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Abstract

This paper presents ISFET array based pH-sensing system-on-ultra-thin-chip (SoUTC) designed and fabricated in 350 nm CMOS technology. The SoUTC with the proposed current-mode active-pixel ISFET circuit array is desined to operate at 2V and consumes 6.28 W per-pixel. The presented SoUTC exhibits low sensitivity to process, voltage, temperature and strain-induced (PVTS) variations. The silicon area occupancy of each active-pixel is 44.9x33.5 m2 with an ion-sensing area of 576 m2. The design of presented ISFET device is analysed with finite element modeling in COMSOL Multiphysics using compact model parameters of MOSFET in 350 nm CMOS technology. Owing to thin (~30m) Si-substrate the presented SoUTC can conform to curvilinear surfaces, allowing intimate contact necessary for reliable data for monitoring of analytes in body fluids such as sweat. Further, it can operate either in a rolling shutter fashion or in a pseudo-random pixel selection mode allowing the simultaneous detection of pH from different skin regions. Finally, the circuits have been tested in aqueous Dulbeccos Modified Eagle Medium (DMEM) culture media with 5-9 pH values, which mimics cellular environments, to demonstrate their potential use for continuous monitoring of body-fluids pH.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Shojaei Baghini, Ms Mahdieh and Vilouras, Anastasios and Dahiya, Professor Ravinder
Authors: Shojaei Baghini, M., Vilouras, A., and Dahiya, R.
College/School:College of Science and Engineering
College of Science and Engineering > School of Engineering > Electronics and Nanoscale Engineering
Journal Name:IEEE Transactions on Biomedical Circuits and Systems
Publisher:IEEE
ISSN:1932-4545
ISSN (Online):1940-9990
Published Online:10 January 2022
Copyright Holders:Copyright © 2022 The Authors
First Published:First published in IEEE Transactions on Biomedical Circuits and Systems 15(6): 1174-1185
Publisher Policy:Reproduced under a Creative Commons License

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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
301728Engineering Fellowships for Growth: Printed Tactile SKINRavinder DahiyaEngineering and Physical Sciences Research Council (EPSRC)EP/R029644/1ENG - Electronics & Nanoscale Engineering
190828EPSRC Centre for Doctoral Training in Sensing and MeasurementAndrew HarveyEngineering and Physical Sciences Research Council (EPSRC)EP/L016753/1P&S - Physics & Astronomy
306720INnovative Network for Training in ToUch InteracTIVE InterfacesRavinder DahiyaEuropean Commission (EC)861166ENG - Electronics & Nanoscale Engineering