Clinical and radiological characteristics of acute pulmonary embolus in relation to 28-day and 6-month mortality

Norton, L. et al. (2021) Clinical and radiological characteristics of acute pulmonary embolus in relation to 28-day and 6-month mortality. PLoS ONE, 16(12), e0258843. (doi: 10.1371/journal.pone.0258843) (PMID:34962922) (PMCID:PMC8714121)

Abstract

Background: Patients with acute pulmonary embolism (PE) exhibit a wide spectrum of clinical and laboratory features when presenting to hospital and pathophysiologic mechanisms differentiating low-risk and high-risk PE are poorly understood. Objectives: To investigate the prognostic value of clinical, laboratory and radiological information that is available within routine tests undertaken for patients with acute PE. Methods: Electronic patient records (EPR) of patients who underwent Computed Tomography Pulmonary Angiogram (CTPA) scan for the investigation of acute PE during 6-month period (01.01.2016–30.06.2016) were examined. Data was gathered from EPR for patients that met inclusion criteria and all CTPA scans were re-evaluated. Biochemical thresholds of low-grade and high-grade inflammation, serum CRP >10mg/L and >150mg/L and serum albumin concentrations <35g/L and <25 g/L, were combined in the Glasgow Prognostic Score (GPS) and peri-operative Glasgow Prognostic Score (poGPS) respectively. Neutrophil Lymphocyte ratio (NLR) was also calculated. Pulmonary Embolus Severity Index score was calculated. Results: Of the total CTPA reports (n = 2129) examined, 245 patients were eligible for inclusion. Of these, 20 (8%) patients had died at 28-days and 43 (18%) at 6-months. Of the 197 non-cancer related presentations, 28-day and 6-month mortality were 3% and 8% respectively. Of the 48 cancer related presentations, 28-day and 6-month mortality were 29% and 58% respectively. On univariate analysis, age ≥65 years (p<0.01), PESI score ≥100(p = <0.001), NLR ≥3(p<0.001) and Coronary Artery Calcification (CAC) score ≥ 6 (p<0.001) were associated with higher 28-day and 6-month mortality. PESI score ≥100 (OR 5.2, 95% CI: 1.1, 24.2, P <0.05), poGPS ≥1 (OR 2.5, 95% CI: 1.2–5.0, P = 0.01) and NLR ≥3 (OR 3.7, 95% CI: 1.0–3.4, P <0.05) remained independently associated with 28-day mortality. On multivariate binary logistic regression analysis of factors associated with 6-month mortality, PESI score ≥100 (OR 6.2, 95% CI: 2.3–17.0, p<0.001) and coronary artery calcification score ≥6 (OR 2.3, 95% CI: 1.1–4.8, p = 0.030) remained independently associated with death at 6-months. When patients who had an underlying cancer diagnosis were excluded from the analysis only GPS≥1 remained independently associated with 6-month mortality (OR 5.0, 95% CI 1.2–22.0, p<0.05). Conclusion: PESI score >100, poGPS≥1, NLR ≥3 and CAC score ≥6 were associated with 28-day and 6-month mortality. PESI score ≥100, poGPS≥1 and NLR ≥3 remained independently associated with 28-day mortality. PESI score ≥100 and CAC score ≥6 remained independently associated with 6-month mortality. When patients with underlying cancer were excluded from the analysis, GPS≥1 remained independently associated with 6-month mortality. The role of the systemic inflammatory response (SIR) in determining treatment and prognosis requires further study. Routine reporting of CAC scores in CTPA scans for acute PE may have a role in aiding clinical decision-making regarding treatment and prognosis.

• Item Type: Articles
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Church, Dr Colin and Sheerins, Mr Owen and Cooper, Dr Gordon and Maguire, Donogh and Tait, Dr Robert and Roditi, Dr Giles and Dolan, Dr Ross and Brady, Dr Adrian

Creator Roles

Cooper, G.: Data curation, Project administration, Supervision, Writing – original draft, Writing – review and editing
Sheerins, O.: Data curation, Writing – review and editing
Roditi, G.: Writing – original draft
Dolan, R.: Conceptualization, Formal analysis, Writing – review and editing
Church, C.: Conceptualization, Writing – review and editing
Brady, A.: Writing – review and editing
Tait, C.: Writing – review and editing
Maguire, D.: Conceptualization, Formal analysis, Methodology, Resources, Supervision, Validation, Visualization

• Authors: Norton, L., Cooper, G., Sheerins, O., Mac a’ Bháird, K., Roditi, G., Adamson, M., Young, D., Dolan, R., Church, C., Brady, A., Tait, C., McKenzie, G., McFadyen, A., Zelic, M., and Maguire, D.
• College/School: College of Medical Veterinary and Life Sciences > School of Cardiovascular & Metabolic Health; College of Medical Veterinary and Life Sciences > School of Medicine, Dentistry & Nursing
• Journal Name: PLoS ONE
• Publisher: Public Library of Science
• ISSN: 1932-6203
• ISSN (Online): 1932-6203
• Copyright Holders: Copyright © 2021 Norton et al.
• First Published: First published in PLoS ONE 16(12): e0258843
• Publisher Policy: Reproduced under a Creative Commons License

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