The influence of nanotopography on cell behaviour through interactions with the extracellular matrix – a review

Luo, J., Walker, M. , Xiao, Y., Donnelly, H., Dalby, M. J. and Salmeron-Sanchez, M. (2022) The influence of nanotopography on cell behaviour through interactions with the extracellular matrix – a review. Bioactive Materials, 15, pp. 145-159. (doi: 10.1016/j.bioactmat.2021.11.024)

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Abstract

Nanotopography presents an effective physical approach for biomaterial cell manipulation mediated through material-extracellular matrix interactions. The extracellular matrix that exists in the cellular microenvironment is crucial for guiding cell behaviours, such as determination of integrin ligation and interaction with growth factors. These interactions with the extracellular matrix regulate downstream mechanotransductive pathways, such as rearrangements in the cytoskeleton and activation of signal cascades. Protein adsorption onto nanotopography strongly influences the conformation and distribution density of extracellular matrix and, therefore, subsequent cell responses. In this review, we first discuss the interactive mechanisms of protein physical adsorption on nanotopography. Secondly, we summarise advances in creating nanotopographical features to instruct desired cell behaviours. Lastly, we focus on the cellular mechanotransductive pathways initiated by nanotopography. This review provides an overview of the current state-of-the-art designs of nanotopography aiming to provide better biomedical materials for the future.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Salmeron-Sanchez, Professor Manuel and Dalby, Professor Matthew and Walker, Dr Matthew and Xiao, Yinbo and Luo, Mr Jiajun and Donnelly, Miss Hannah
Authors: Luo, J., Walker, M., Xiao, Y., Donnelly, H., Dalby, M. J., and Salmeron-Sanchez, M.
College/School:College of Medical Veterinary and Life Sciences > Institute of Biodiversity Animal Health and Comparative Medicine
College of Science and Engineering > School of Engineering > Biomedical Engineering
College of Medical Veterinary and Life Sciences > Institute of Cancer Sciences
Journal Name:Bioactive Materials
Publisher:Elsevier
ISSN:2452-199X
ISSN (Online):2452-199X
Published Online:21 December 2021
Copyright Holders:Copyright © 2021 The Authors
First Published:First published in Bioactive Materials 15: 145-159
Publisher Policy:Reproduced under a Creative Commons Licence

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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
308668Engineered substrates for the isolation and expansion of mesenchymal stem cellsManuel Salmeron-SanchezLeverhulme Trust (LEVERHUL)RPG-2019-252ENG - Biomedical Engineering
173192Engineering growth factor microenvironments- a new therapeutic paradigm for regenerative medicineManuel Salmeron-SanchezEngineering and Physical Sciences Research Council (EPSRC)EP/P001114/1ENG - Biomedical Engineering