Luo, J., Walker, M. , Xiao, Y., Donnelly, H., Dalby, M. J. and Salmeron-Sanchez, M. (2022) The influence of nanotopography on cell behaviour through interactions with the extracellular matrix – a review. Bioactive Materials, 15, pp. 145-159. (doi: 10.1016/j.bioactmat.2021.11.024)
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Abstract
Nanotopography presents an effective physical approach for biomaterial cell manipulation mediated through material-extracellular matrix interactions. The extracellular matrix that exists in the cellular microenvironment is crucial for guiding cell behaviours, such as determination of integrin ligation and interaction with growth factors. These interactions with the extracellular matrix regulate downstream mechanotransductive pathways, such as rearrangements in the cytoskeleton and activation of signal cascades. Protein adsorption onto nanotopography strongly influences the conformation and distribution density of extracellular matrix and, therefore, subsequent cell responses. In this review, we first discuss the interactive mechanisms of protein physical adsorption on nanotopography. Secondly, we summarise advances in creating nanotopographical features to instruct desired cell behaviours. Lastly, we focus on the cellular mechanotransductive pathways initiated by nanotopography. This review provides an overview of the current state-of-the-art designs of nanotopography aiming to provide better biomedical materials for the future.
| Item Type: | Articles |
|---|---|
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Salmeron-Sanchez, Professor Manuel and Dalby, Professor Matthew and Walker, Dr Matthew and Xiao, Yinbo and Luo, Mr Jiajun and Donnelly, Dr Hannah |
| Authors: | Luo, J., Walker, M., Xiao, Y., Donnelly, H., Dalby, M. J., and Salmeron-Sanchez, M. |
| College/School: | College of Science and Engineering > School of Engineering > Biomedical Engineering College of Medical Veterinary and Life Sciences > School of Cancer Sciences College of Medical Veterinary and Life Sciences > School of Biodiversity, One Health & Veterinary Medicine |
| Journal Name: | Bioactive Materials |
| Publisher: | Elsevier |
| ISSN: | 2452-199X |
| ISSN (Online): | 2452-199X |
| Published Online: | 21 December 2021 |
| Copyright Holders: | Copyright © 2021 The Authors |
| First Published: | First published in Bioactive Materials 15: 145-159 |
| Publisher Policy: | Reproduced under a Creative Commons Licence |
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