Pink pressure: beetroot (Beta vulgaris rubra) as a possible novel medical therapy for chronic kidney disease

de Souza Gouveia Moreira, L., Fanton, S., Cardozo, L., Borges, N. A., Combet, E. , Shiels, P. G. , Stenvinkel, P. and Mafra, D. (2022) Pink pressure: beetroot (Beta vulgaris rubra) as a possible novel medical therapy for chronic kidney disease. Nutrition Reviews, 80(5), pp. 1041-1061. (doi: 10.1093/nutrit/nuab074) (PMID:34613396)

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Abstract

Chronic kidney disease (CKD) manifests with systemic inflammation, oxidative stress, and gut dysbiosis, resulting in metabolic disorders and elevated rates of cardiovascular disease–associated death. These all correlate with a high economic cost to healthcare systems. Growing evidence indicates that diet is an indispensable ally in the prevention and management of CKD and its complications. In this context, the root vegetable beetroot (Beta vulgaris rubra) deserves special attention because it is a source of several bioactive compounds, such as nitrate, betaine, and betalain, and has shown beneficial effects in CKD, including reduction of blood pressure, anti-inflammatory effects, and antioxidant actions by scavenging radical oxidative species, as observed in preclinical studies. Beetroot consumption as a possible therapeutic strategy to improve the clinical treatment of patients with CKD and future directions for clinical studies are addressed in this narrative review.

Item Type:Articles
Additional Information:Funding: D.M. is supported by Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq), Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) and Fundação de Amparo à Pesquisa do Estado do Rio de Janeiro (FAPERJ). P.S. is supported by The Heart and Lung Foundation, Karolinska Institutet Diabetic Theme Centre, INTRICARE, CaReSyAn and “Njurfonden” and also by Baxter Novum that is the result of a grant from Baxter Healthcare to Karolinska Institutet.
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Mafra, Prof Denise and Combet Aspray, Professor Emilie and Shiels, Professor Paul
Authors: de Souza Gouveia Moreira, L., Fanton, S., Cardozo, L., Borges, N. A., Combet, E., Shiels, P. G., Stenvinkel, P., and Mafra, D.
College/School:College of Medical Veterinary and Life Sciences > Institute of Cancer Sciences
College of Medical Veterinary and Life Sciences > School of Medicine, Dentistry & Nursing
Journal Name:Nutrition Reviews
Publisher:Oxford University Press
ISSN:0029-6643
ISSN (Online):1753-4887
Published Online:06 October 2021

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