Ultra-thin ISFET-based sensing systems

Shojaei Baghini, M. , Vilouras, A. , Douthwaite, M., Georgiou, P. and Dahiya, R. (2021) Ultra-thin ISFET-based sensing systems. Electrochemical Science Advances, (doi: 10.1002/elsa.202100202) (Early Online Publication)

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The ion-sensitive field effect transistors (ISFETs), proposed little over 50 years ago, today make the most promising devices for lab-on-a-chip, implantable, and point-of-care (POC) diagnostics. Their compatibility with CMOS (Complementary Metal Oxide Semiconductor) technology and the low cost through mass production have been the driving factors so far. Nowadays, they are also being developed in flexible form factors for new applications such as wearables and to improve the effective usage in existing applications such as implantable systems. In this regard, the CMOS ultra-thin chip (UTC) technology and the bonding by printing are the noteworthy advances. This paper comprehensively reviews such new developments in the CMOS-compatible ISFETs, along with their theory, readout circuitries, circuit-based techniques for compensation of the ISFET's instabilities, such as the offset, flicker noise, and drift. The sensing mechanisms and the properties of interface between the electrolyte under test and the metal-oxide based ion-sensitive electrodes have been discussed along with a brief overview of the metal-oxide based pH sensors. An overview of the reported mechanically flexible pH sensors, including ISFETs, is provided and the history of ISFET applications are also covered. Finally, established models that can be used to design flexible circuits are presented, and possible opportunities to use circuit techniques to compensate for mechanical deformation are discussed.

Item Type:Articles
Additional Information:This work is supported by Engineering and Physical Sciences Research Council (EPSRC) through Engineering Fellowship for Growth (EP/R029644/1) and the Centre for Doctoral Training in Intelligent Sensing and Measurement (EP/L016753/1). This work is also supported by the European Commission (EU) through the Innovative Network for Training in Touch Interactive Interfaces (INTUITIVE, project #861166).
Status:Early Online Publication
Glasgow Author(s) Enlighten ID:Shojaei Baghini, Ms Mahdieh and Vilouras, Anastasios and Dahiya, Professor Ravinder
Authors: Shojaei Baghini, M., Vilouras, A., Douthwaite, M., Georgiou, P., and Dahiya, R.
College/School:College of Science and Engineering
College of Science and Engineering > School of Engineering > Electronics and Nanoscale Engineering
Journal Name:Electrochemical Science Advances
ISSN (Online):2698-5977
Published Online:16 December 2021
Copyright Holders:Copyright © 2021 The Authors
First Published:First published in Electrochemical Science Advances 2021
Publisher Policy:Reproduced under a Creative Commons licence

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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
301728Engineering Fellowships for Growth: Printed Tactile SKINRavinder DahiyaEngineering and Physical Sciences Research Council (EPSRC)EP/R029644/1ENG - Electronics & Nanoscale Engineering
190828EPSRC Centre for Doctoral Training in Sensing and MeasurementAndrew HarveyEngineering and Physical Sciences Research Council (EPSRC)EP/L016753/1P&S - Physics & Astronomy
306720INnovative Network for Training in ToUch InteracTIVE InterfacesRavinder DahiyaEuropean Commission (EC)861166ENG - Electronics & Nanoscale Engineering