Synthetic ligustrazine based cyclohexanone and oxime analogs as Anti-Trypanosoma and Anti-Leishmanial agentes

Alkhaldi, A. A.M., De Koning, H. P. and Bukhari, S. N. A. (2021) Synthetic ligustrazine based cyclohexanone and oxime analogs as Anti-Trypanosoma and Anti-Leishmanial agentes. Brazilian Journal of Pharmaceutical Sciences, 57, e18997. (doi: 10.1590/s2175-97902020000418997)

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Abstract

In the present study a series of 34 synthetic ligustrazine-containing α, β-Unsaturated carbonyl-based compounds and oximes, recognized as anticancer compounds were assessed against protozoa of the Trypanosoma and Leishmania species. Ligustrazine, chemically known as tetramethylpyrazine (TMP), was selected as the core moiety for the synthesis of α, β-Unsaturated carbonyl-based compounds and these compounds were selected as precursors for the synthesis of new oximes. Some derivates, including 5f and 6i, showed multiple activities against all tested strains. In particular compounds 5f and 8o are the most potent and they are, therefore, potential candidates for trypanosomiasis and leishmaniasis

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:De Koning, Professor Harry
Authors: Alkhaldi, A. A.M., De Koning, H. P., and Bukhari, S. N. A.
College/School:College of Medical Veterinary and Life Sciences > School of Infection & Immunity
Journal Name:Brazilian Journal of Pharmaceutical Sciences
Publisher:Universidade de Sao Paulo
ISSN:1984-8250
ISSN (Online):2175-9790
Published Online:18 October 2021
Copyright Holders:Copyright © 2019 The Authors
First Published:First published in Brazilian Journal of Pharmaceutical Sciences 57:e18997
Publisher Policy:Reproduced under a Creative Commons License

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