Associations of A Body Shape Index (ABSI) with cancer incidence, all-cause and at 23 sites- Findings from the UK Biobank prospective cohort study

Parra-Soto, S., Malcomson, F. C., Ho, F. K., Pell, J. P. , Sharp, L., Mathers, J. C. and Celis-Morales, C. (2022) Associations of A Body Shape Index (ABSI) with cancer incidence, all-cause and at 23 sites- Findings from the UK Biobank prospective cohort study. Cancer Epidemiology, Biomarkers and Prevention, 31(2), pp. 315-324. (doi: 10.1158/1055-9965.EPI-21-0591) (PMID:34853021)

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Abstract

Background: Few studies have explored the emerging adiposity marker A Body Shape Index (ABSI) with cancer risk. This study investigated the associations between ABSI and the incidence of cancer at 23 sites and all cancer combined. Methods: Data from 442614 participants from the UK Biobank prospective study were included in this study. ABSI was used as the exposure. Incidence of cancer at 23 sites were the outcomes. Cox-proportional hazard models were performed to explore the association of ABSI, and combined ABSI and BMI with cancer risk, after adjusting for multiple testing. Results: 36961 individuals developed cancer during the 8.8 years median follow-up. In multivariable analyses, participants in the highest tertile of ABSI had higher risk of lung (HR 1.58 [1.44;1.74]), liver (HR:1.45 [1.18;1.77]), oesophagus (HR: 1.32 [95% CI: 1.12;1.57]) and colorectal (HR:1.19 [1.10;1.28]), breast (HR: 1.05 [1.04;1.17]) cancers, and all cancers combined (HR:1.11 [1.08;1.14]) compared with the lowest tertile. These associations remained significant after adjustment for BMI. When ABSI was combined with BMI, participants in the highest ABSI who also had a BMI{greater than or equal to}25kg/m2 were at higher risk of uterus, oesophagus, liver, stomach, colorectal and breast cancers, as well as all cancers combined, compared with those in the lowest ABSI tertile with a normal BMI. Conclusion: ABSI is associated with an increased risk of five cancers as well as all cancers combined, independently of BMI. Impact: ABSI is a useful marker for adiposity. However, cancer risk prediction improves with the combination of BMI.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Ho, Dr Frederick and Celis, Dr Carlos and Pell, Professor Jill and Parra, Solange
Authors: Parra-Soto, S., Malcomson, F. C., Ho, F. K., Pell, J. P., Sharp, L., Mathers, J. C., and Celis-Morales, C.
College/School:College of Medical Veterinary and Life Sciences > Institute of Cardiovascular and Medical Sciences
College of Medical Veterinary and Life Sciences > Institute of Health and Wellbeing > Public Health
Journal Name:Cancer Epidemiology, Biomarkers and Prevention
Publisher:American Association for Cancer Research
ISSN:1055-9965
ISSN (Online):1538-7755
Published Online:30 November 2021
Copyright Holders:Copyright © 2021 American Association for Cancer Research
First Published:First published in Cancer Epidemiology, Biomarkers and Prevention 31(2): 315-324
Publisher Policy:Reproduced in accordance with the publisher copyright policy

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