Dose-response association between device-measured physical activity and incident dementia: a prospective study from UK Biobank

Petermann-Rocha, F. et al. (2021) Dose-response association between device-measured physical activity and incident dementia: a prospective study from UK Biobank. BMC Medicine, 19, 305. (doi: 10.1186/s12916-021-02172-5)

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Background: Previous cohort studies have investigated the relationship between self-reported physical activity (PA) and dementia. Evidence from objective device-measured PA data is lacking. This study aimed to explore the association of device-measured PA with the risk of dementia incidence and common subtypes (Alzheimer’s disease [AD] and vascular dementia) using the UK Biobank study. Methods: 84,854 participants (55.8% women), invited to participate in the device-measured PA between 2013 and 2015, were included in this prospective cohort study. Wrist accelerometers were used to measure light, moderate, vigorous, moderate-to-vigorous PA (MVPA) and total PA intensity and duration (MET/min/week). Incident dementia (fatal and non-fatal) was extracted from hospital episodes records for incidence and death register for mortality. Incidence follow-up was carried out until the end of March 2021in England and Scotland and the end of March 2018 in Wales. Mortality data were available until February 2021. Nonlinear associations were first investigated using penalised cubic splines fitted in the Cox proportional hazard models. In addition, using MVPA, five categories were created. Associations of these categories with the outcomes were investigated using Cox proportional hazard models. Analyses were adjusted for sociodemographic, lifestyle and health-related factors. Results: After a median follow-up of 6.3 years, 678 individuals were diagnosed with dementia. Evidence of nonlinearity was observed for all PA modes and all-cause dementia. For categories of MVPA, there was a significant trend towards a low risk of overall dementia when higher levels of MVPA were achieved (HRtrend 0.66 [95% CI 0.62 to 0.70]. The lowest risk was identified in individuals who performed more than 1200 MET/min/week, those who had 84% (95% CI 0.12 to 0.21) lower risk of incident dementia compared to those who performed < 300 MET/min/week. Conclusions: Participants with higher PA levels had a lower risk of incident dementia than those less active, independently of sociodemographic, lifestyle factors and comorbidity. Considering that the majority of previous studies have reported this association using self-reported data, our findings highlight the strong inverse association between PA objectively measured and incident dementia.

Item Type:Articles
Additional Information:The UK Biobank was established by the Wellcome Trust medical charity, Medical Research Council, Department of Health, Scottish Government and the Northwest Regional Development Agency. It has also had funding from the Welsh Assembly Government and the British Heart Foundation. All authors had final responsibility for submission for publication. FP-R receives financial support from the Chilean Government for doing her PhD (ANID-Becas Chile 2018 – 72190067).
Glasgow Author(s) Enlighten ID:Ho, Dr Frederick and Welsh, Dr Paul and Celis, Dr Carlos and Gray, Professor Stuart and Pell, Professor Jill and Quinn, Dr Terry and Sattar, Professor Naveed and Lyall, Dr Donald and Stewart, Dr William and Gill, Professor Jason and Petermann-Rocha, Mrs Fanny
Authors: Petermann-Rocha, F., Lyall, D. M., Gray, S. R., Gill, J. M.R., Sattar, N., Welsh, P., Quinn, T. J., Stewart, W., Pell, J. P., Ho, F. K., and Celis-Morales, C.
College/School:College of Medical Veterinary and Life Sciences > School of Cardiovascular & Metabolic Health
College of Medical Veterinary and Life Sciences > School of Health & Wellbeing > Public Health
College of Medical Veterinary and Life Sciences > School of Psychology & Neuroscience
Journal Name:BMC Medicine
Publisher:BioMed Central
ISSN (Online):1741-7015
Copyright Holders:Copyright © 2021 The Authors
First Published:First published in BMC Medicine 19: 305
Publisher Policy:Reproduced under a Creative Commons License

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