Antimalarial effects of the hydroalcoholic extract of Allium paradoxum in vitro and in vivo

Elmi, T., Hajialiani, F., Asadi, M. R., Sadeghi, S., Namazi, M. J., Tabatabaie, F. and Zamani, Z. (2021) Antimalarial effects of the hydroalcoholic extract of Allium paradoxum in vitro and in vivo. Journal of Parasitic Diseases, 45(4), pp. 1055-1064. (doi: 10.1007/s12639-021-01359-0) (PMID:34789989)

Abstract

Malaria still is the most fatal parasitic disease affecting 50% of the world's population. Although annual deaths attributed to malaria has reduced, crucial importance of its prevention and treatment remains a priority for health care systems and researchers. The worldwide increase in resistance to most common antimalarial drugs such as chloroquine, their unpleasant side effects and low efficiencies persuade researchers to prioritize finding alternative drugs including herbal medication from plant roots. The present study aimed to examine in vitro and in vivo effects of hydroalcoholic extract of herbal medicinal plant, on growth rate in and The cytotoxicity assay was performed for hydroalcoholic extract of . The 3D7 strain of was cultured. The IC assay and enzymatic activity of lactate dehydrogenase were performed. BALB/c mice were infected with in vivo Toxicity and histopathological changes in the tissues of liver and kidney were also examined. The highest efficacy of extract was observed at 80 μg/mL in culture resulting in 60.43% growth inhibition compared to control groups. The significantly highest parasite growth inhibition with 88.71% was seen in the mice infected with when administered with 400 mg/kg extract compared to control groups. No significant changes in the liver and kidney cells were observed between experimental and control groups. The study showed that extract exhibited significant antimalarial properties in vitro on and in vivo in mice infected with There was no significant toxicity in the liver and kidney of the treated mice. [Abstract copyright: © Indian Society for Parasitology 2021.]

• Item Type: Articles
• Additional Information: This work was supported by Iran University of Medical Sciences [Grant Code: 97–02-30–33789].
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Namazi, Dr Mohammad
• Authors: Elmi, T., Hajialiani, F., Asadi, M. R., Sadeghi, S., Namazi, M. J., Tabatabaie, F., and Zamani, Z.
• College/School: College of Medical Veterinary and Life Sciences > School of Infection & Immunity
• Journal Name: Journal of Parasitic Diseases
• Publisher: Springer
• ISSN: 0971-7196
• ISSN (Online): 0975-0703
• Published Online: 12 May 2021