DeepSinse: deep learning-based detection of single molecules

Danial, J. S. H., Shalaby, R., Cosentino, K., Mahmoud, M. M. , Medhat, F., Klenerman, D. and Garcia Saez, A. J. (2021) DeepSinse: deep learning-based detection of single molecules. Bioinformatics, 37(21), pp. 3998-4000. (doi: 10.1093/bioinformatics/btab352) (PMID:33964131)

Abstract

Motivation: Imaging single molecules has emerged as a powerful characterization tool in the biological sciences. The detection of these under various noise conditions requires the use of algorithms that are dependent on the enduser inputting several parameters, the choice of which can be challenging and subjective. Results: In this work, we propose DeepSinse, an easily trainable and useable deep neural network that can detect single molecules with little human input and across a wide range of signal-to-noise ratios. We validate the neural network on the detection of single bursts in simulated and experimental data and compare its performance with the best-in-class, domain-specific algorithms.

• Item Type: Articles
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Mahmoud, Dr Marwa
• Authors: Danial, J. S. H., Shalaby, R., Cosentino, K., Mahmoud, M. M., Medhat, F., Klenerman, D., and Garcia Saez, A. J.
• College/School: College of Science and Engineering > School of Computing Science
• Journal Name: Bioinformatics
• Publisher: Oxford University Press
• ISSN: 1367-4803
• ISSN (Online): 1460-2059
• Published Online: 08 May 2021
• Copyright Holders: Copyright © 2021 The Authors
• First Published: First published in Bioinformatics 37(21): 3998-4000
• Publisher Policy: Reproduced in accordance with the publisher copyright policy