Insights into vitamin K metabolism in chronic kidney disease: more complicated than kale deficiency

Lees, J. S. and Mark, P. B. (2022) Insights into vitamin K metabolism in chronic kidney disease: more complicated than kale deficiency. Kidney International, 101(2), pp. 216-219. (doi: 10.1016/j.kint.2021.11.022) (PMID:35065688)

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Abstract

Vascular calcification is a major manifestation of cardiovascular disease in advanced chronic kidney disease and is inhibited by vitamin K–dependent proteins. Clinical trials of vitamin K supplementation in chronic kidney disease have failed to demonstrate benefits on vascular calcification. Recent laboratory, human, and animal studies have shown that vitamin K handling and metabolism in chronic kidney disease is complex and suggest vitamin K2 subtype supplementation in isolation is unlikely to have significant clinical impact.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Mark, Professor Patrick and Lees, Jennifer
Authors: Lees, J. S., and Mark, P. B.
College/School:College of Medical Veterinary and Life Sciences > School of Cardiovascular & Metabolic Health
Journal Name:Kidney International
Publisher:Elsevier
ISSN:0085-2538
ISSN (Online):1523-1755
Published Online:19 January 2022
Copyright Holders:Copyright © 2022 International Society of Nephrology
First Published:First published in Kidney International 101(2):216-219
Publisher Policy:Reproduced in accordance with the copyright policy of the publisher

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