Insights into vitamin K metabolism in chronic kidney disease: more complicated than kale deficiency

Lees, J. S. and Mark, P. B. (2022) Insights into vitamin K metabolism in chronic kidney disease: more complicated than kale deficiency. Kidney International, 101(2), pp. 216-219. (doi: 10.1016/j.kint.2021.11.022) (PMID:35065688)

Abstract

Vascular calcification is a major manifestation of cardiovascular disease in advanced chronic kidney disease and is inhibited by vitamin K–dependent proteins. Clinical trials of vitamin K supplementation in chronic kidney disease have failed to demonstrate benefits on vascular calcification. Recent laboratory, human, and animal studies have shown that vitamin K handling and metabolism in chronic kidney disease is complex and suggest vitamin K2 subtype supplementation in isolation is unlikely to have significant clinical impact.

• Item Type: Articles
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Mark, Professor Patrick and Lees, Jennifer
• Authors: Lees, J. S., and Mark, P. B.
• College/School: College of Medical Veterinary and Life Sciences > School of Cardiovascular & Metabolic Health
• Journal Name: Kidney International
• Publisher: Elsevier
• ISSN: 0085-2538
• ISSN (Online): 1523-1755
• Published Online: 19 January 2022
• Copyright Holders: Copyright © 2022 International Society of Nephrology
• First Published: First published in Kidney International 101(2):216-219
• Publisher Policy: Reproduced in accordance with the copyright policy of the publisher