A double-blind, clinical evaluation of facial augmentation treatments: a comparison of PRI 1, PRI 2, Zyplast® and Perlane®

Downie, J.J., Mao, Z.L., Lo, T.W.R., Barry, S. , Bock, M., Siebert, J.P., Bowman, A. and Ayoub, A.F. (2009) A double-blind, clinical evaluation of facial augmentation treatments: a comparison of PRI 1, PRI 2, Zyplast® and Perlane®. Journal of Plastic, Reconstructive and Aesthetic Surgery, 62(12), pp. 1636-1643. (doi:10.1016/j.bjps.2008.06.056)

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Abstract

<b>Background</b>: Facial wrinkles are caused by weakening of the sub-dermal collagen support layer. Dermal fillers can be used to treat wrinkles, and this double-blind, randomised, single-centre study compared four fillers: PRI 1, PRI 2 (both porcine collagen), Zyplast® (purified bovine collagen) and Perlane® (cross-linked hyaluronic acid gel). <b>Methods</b>: 79 females (aged 25–55 years) with wrinkles in the upper lip line border were randomised to PRI 1 (19 patients), PRI 2 (19 patients), Perlane® (23 patients), Zyplast® (18 patients). Patients were assessed at 1 week and 1, 3, 6, 9 and 12 months using 2D images and by mathematically derived facial volume changes using 3D stereophotogrammetry. <b>Results</b>: All treatments produced larger, less wrinkled, more prominent lips. PRI 1, PRI 2 and Zyplast® showed similar lip volume gains, with Perlane® showing the greatest upper lip volume increase. All treatments were comparable for rates of decrease in upper lip volume post-treatment, however, Perlane® maintained higher lip volume gains at each time point. Investigators indicated PRI 1 was significantly easier to deliver than Zyplast®. Patient satisfaction scores were similar, though there was a trend towards greater dissatisfaction for PRI 1 and PRI 2 at month 9 (p = 0.052). Treatment was well-tolerated, with ‘cold sore’ being the most common adverse event. <b>Conclusions</b>: Results showed that PRI 1 and PRI 2 were comparable to Perlane® and Zyplast® as dermal fillers. Further rigorous studies are required to establish the performance of dermal fillers and patient acceptability. We propose the utilisation of stereophotogrammetry for assessment of volume changes.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Downie, Mr John and Ayoub, Professor Ashraf and Bowman, Professor Adrian and Siebert, Dr Jan and Barry, Dr Sarah and Bock, Dr Mitchum
Authors: Downie, J.J., Mao, Z.L., Lo, T.W.R., Barry, S., Bock, M., Siebert, J.P., Bowman, A., and Ayoub, A.F.
Subjects:R Medicine > R Medicine (General)
College/School:College of Medical Veterinary and Life Sciences > Institute of Health and Wellbeing > Robertson Centre
College of Medical Veterinary and Life Sciences > School of Medicine, Dentistry & Nursing > Dental School
College of Science and Engineering > School of Computing Science
College of Science and Engineering > School of Mathematics and Statistics > Statistics
Journal Name:Journal of Plastic, Reconstructive and Aesthetic Surgery
ISSN:1748-6815
ISSN (Online):1532-1959
Published Online:04 November 2008

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