Unhealthy lifestyle, genetics and risk of cardiovascular disease and mortality in 76,958 individuals from the UK Biobank cohort study

Livingstone, K. M., Abbott, G., Ward, J. and Bowe, S. J. (2021) Unhealthy lifestyle, genetics and risk of cardiovascular disease and mortality in 76,958 individuals from the UK Biobank cohort study. Nutrients, 13(12), 4283. (doi: 10.3390/nu13124283)

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Abstract

To examine associations of unhealthy lifestyle and genetics with risk of all-cause mortality, cardiovascular disease (CVD) mortality, myocardial infarction (MI) and stroke. We used data on 76,958 adults from the UK Biobank prospective cohort study. Favourable lifestyle included no overweight/obesity, not smoking, physical activity, not sedentary, healthy diet and adequate sleep. A Polygenic Risk Score (PRS) was derived using 300 CVD-related single nucleotide polymorphisms. Cox proportional hazard ratios (HR) were used to model effects of lifestyle and PRS on risk of CVD and all-cause mortality, stroke and MI. New CVD (n = 364) and all-cause (n = 2408) deaths, and stroke (n = 748) and MI (n = 1140) events were observed during a 7.8 year mean follow-up. An unfavourable lifestyle (0−1 healthy behaviours) was associated with higher risk of all-cause mortality (HR: 2.06; 95% CI: 1.73, 2.45), CVD mortality (HR: 2.48; 95% CI: 1.64, 3.76), MI (HR: 2.12; 95% CI: 1.65, 2.72) and stroke (HR:1.74; 95% CI: 1.25, 2.43) compared to a favourable lifestyle (≥4 healthy behaviours). PRS was associated with MI (HR: 1.35; 95% CI: 1.27, 1.43). There was evidence of a lifestyle-genetics interaction for stroke (p = 0.017). Unfavourable lifestyle behaviours predicted higher risk of all-cause mortality, CVD mortality, MI and stroke, independent of genetic risk.

Item Type:Articles
Additional Information:K.M.L. is supported by a National Health and Medical Research Council Emerging Leadership Fellowship (APP1173803). J.W. is funded by the Lister Prize Fellowship (173096).
Keywords:Healthy lifestyle, genetic risk, cardiovascular disease, mortality, myocardial infarction, stroke.
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Ward, Dr Joey
Creator Roles:
Ward, J.Writing – review and editing
Authors: Livingstone, K. M., Abbott, G., Ward, J., and Bowe, S. J.
College/School:College of Medical Veterinary and Life Sciences > Institute of Health and Wellbeing > Mental Health and Wellbeing
Journal Name:Nutrients
Publisher:MDPI
ISSN:2072-6643
ISSN (Online):2072-6643
Published Online:27 November 2021
Copyright Holders:Copyright © 2021 The Authors
First Published:First published in Nutrients 13(12): 4283
Publisher Policy:Reproduced under a Creative Commons License

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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
173096Investigating comorbidity between hypertension and bipolar disorder to identify new and repurposed medications for bipolar disorderDaniel SmithLister Institute of Preventive Medicine (LISTININ)Research Prize 2016HW - Mental Health and Wellbeing