Livingstone, K. M., Abbott, G., Ward, J. and Bowe, S. J. (2021) Unhealthy lifestyle, genetics and risk of cardiovascular disease and mortality in 76,958 individuals from the UK Biobank cohort study. Nutrients, 13(12), 4283. (doi: 10.3390/nu13124283)
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Abstract
To examine associations of unhealthy lifestyle and genetics with risk of all-cause mortality, cardiovascular disease (CVD) mortality, myocardial infarction (MI) and stroke. We used data on 76,958 adults from the UK Biobank prospective cohort study. Favourable lifestyle included no overweight/obesity, not smoking, physical activity, not sedentary, healthy diet and adequate sleep. A Polygenic Risk Score (PRS) was derived using 300 CVD-related single nucleotide polymorphisms. Cox proportional hazard ratios (HR) were used to model effects of lifestyle and PRS on risk of CVD and all-cause mortality, stroke and MI. New CVD (n = 364) and all-cause (n = 2408) deaths, and stroke (n = 748) and MI (n = 1140) events were observed during a 7.8 year mean follow-up. An unfavourable lifestyle (0−1 healthy behaviours) was associated with higher risk of all-cause mortality (HR: 2.06; 95% CI: 1.73, 2.45), CVD mortality (HR: 2.48; 95% CI: 1.64, 3.76), MI (HR: 2.12; 95% CI: 1.65, 2.72) and stroke (HR:1.74; 95% CI: 1.25, 2.43) compared to a favourable lifestyle (≥4 healthy behaviours). PRS was associated with MI (HR: 1.35; 95% CI: 1.27, 1.43). There was evidence of a lifestyle-genetics interaction for stroke (p = 0.017). Unfavourable lifestyle behaviours predicted higher risk of all-cause mortality, CVD mortality, MI and stroke, independent of genetic risk.
Item Type: | Articles |
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Additional Information: | K.M.L. is supported by a National Health and Medical Research Council Emerging Leadership Fellowship (APP1173803). J.W. is funded by the Lister Prize Fellowship (173096). |
Keywords: | Healthy lifestyle, genetic risk, cardiovascular disease, mortality, myocardial infarction, stroke. |
Status: | Published |
Refereed: | Yes |
Glasgow Author(s) Enlighten ID: | Ward, Dr Joey |
Creator Roles: | |
Authors: | Livingstone, K. M., Abbott, G., Ward, J., and Bowe, S. J. |
College/School: | College of Medical Veterinary and Life Sciences > School of Health & Wellbeing > Mental Health and Wellbeing |
Journal Name: | Nutrients |
Publisher: | MDPI |
ISSN: | 2072-6643 |
ISSN (Online): | 2072-6643 |
Published Online: | 27 November 2021 |
Copyright Holders: | Copyright © 2021 The Authors |
First Published: | First published in Nutrients 13(12): 4283 |
Publisher Policy: | Reproduced under a Creative Commons License |
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