Nanoparticle theranostics in cardiovascular inflammation

MacRitchie, N., Di Francesco, V., Ferreira, M. F. M. M., Guzik, T. J., Decuzzi, P. and Maffia, P. (2021) Nanoparticle theranostics in cardiovascular inflammation. Seminars in Immunology, 56, 101536. (doi: 10.1016/j.smim.2021.101536) (PMID:34862118) (PMCID:PMC8811479)

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Abstract

Theranostics, literally derived from the combination of the words diagnostics and therapy, is an emerging field of clinical and preclinical research, where contrast agents, drugs and diagnostic techniques are combined to simultaneously diagnose and treat pathologies. Nanoparticles are extensively employed in theranostics due to their potential to target specific organs and their multifunctional capacity. In this review, we will discuss the current state of theranostic nanomedicine, providing key examples of its application in the imaging and treatment of cardiovascular inflammation.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Maffia, Professor Pasquale and Guzik, Professor Tomasz and MacRitchie, Dr Neil
Authors: MacRitchie, N., Di Francesco, V., Ferreira, M. F. M. M., Guzik, T. J., Decuzzi, P., and Maffia, P.
College/School:College of Medical Veterinary and Life Sciences > Institute of Cardiovascular and Medical Sciences
College of Medical Veterinary and Life Sciences > Institute of Infection Immunity and Inflammation
Journal Name:Seminars in Immunology
Publisher:Elsevier
ISSN:1044-5323
ISSN (Online):1096-3618
Published Online:30 November 2021
Copyright Holders:Copyright © 2021 The Authors
First Published:First published in Seminars in Immunology 2021
Publisher Policy:Reproduced under a Creative Commons License

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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
308639Defining the individual and integrated roles of inflammatory chemokine receptors (iCCRs) in atherosclerosisPasquale MaffiaBritish Heart Foundation (BHF)PG/19/84/34771CAMS - Cardiovascular Science
313479Defining AXL Role in AtherosclerosisPasquale MaffiaBritish Heart Foundation (BHF)PG/21/10541CAMS - Cardiovascular Science
190739In Situ Nanoparticle Assemblies for Healthcare Diagnostics and Therapy. Reference: 130479Pasquale MaffiaEngineering and Physical Sciences Research Council (EPSRC)EP/L014165/1III - Immunology
300798A study of the roles of the immune and inflammatory systems in hypertensionTomasz GuzikEuropean Research Council (ERC)726318CAMS - Cardiovascular Science
173707Institutional Strategic Support Fund (2016)Anna DominiczakWellcome Trust (WELLCOTR)204820/Z/16/ZInstitute of Cardiovascular & Medical Sciences