Nanoparticle theranostics in cardiovascular inflammation

MacRitchie, N., Di Francesco, V., Ferreira, M. F. M. M., Guzik, T. J., Decuzzi, P. and Maffia, P. (2021) Nanoparticle theranostics in cardiovascular inflammation. Seminars in Immunology, 56, 101536. (doi: 10.1016/j.smim.2021.101536) (PMID:34862118) (PMCID:PMC8811479)

Abstract

Theranostics, literally derived from the combination of the words diagnostics and therapy, is an emerging field of clinical and preclinical research, where contrast agents, drugs and diagnostic techniques are combined to simultaneously diagnose and treat pathologies. Nanoparticles are extensively employed in theranostics due to their potential to target specific organs and their multifunctional capacity. In this review, we will discuss the current state of theranostic nanomedicine, providing key examples of its application in the imaging and treatment of cardiovascular inflammation.

• Item Type: Articles
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Maffia, Professor Pasquale and Guzik, Professor Tomasz and MacRitchie, Dr Neil
• Authors: MacRitchie, N., Di Francesco, V., Ferreira, M. F. M. M., Guzik, T. J., Decuzzi, P., and Maffia, P.
• College/School: College of Medical Veterinary and Life Sciences > School of Cardiovascular & Metabolic Health; College of Medical Veterinary and Life Sciences > School of Infection & Immunity
• Research Centre: College of Medical Veterinary and Life Sciences > School of Infection & Immunity > Centre for Immunobiology
• Journal Name: Seminars in Immunology
• Publisher: Elsevier
• ISSN: 1044-5323
• ISSN (Online): 1096-3618
• Published Online: 30 November 2021
• Copyright Holders: Copyright © 2021 The Authors
• First Published: First published in Seminars in Immunology 2021
• Publisher Policy: Reproduced under a Creative Commons License

Project Code	Award No	Project Name	Principal Investigator	Funder's Name	Funder Ref	Lead Dept
308639		Defining the individual and integrated roles of inflammatory chemokine receptors (iCCRs) in atherosclerosis	Pasquale Maffia	British Heart Foundation (BHF)	PG/19/84/34771	CAMS - Cardiovascular Science
313479		Defining AXL Role in Atherosclerosis	Pasquale Maffia	British Heart Foundation (BHF)	PG/21/10541	CAMS - Cardiovascular Science
190739		In Situ Nanoparticle Assemblies for Healthcare Diagnostics and Therapy. Reference: 130479	Pasquale Maffia	Engineering and Physical Sciences Research Council (EPSRC)	EP/L014165/1	III - Immunology
300798		A study of the roles of the immune and inflammatory systems in hypertension	Tomasz Guzik	European Research Council (ERC)	726318	CAMS - Cardiovascular Science
173707		Institutional Strategic Support Fund (2016)	Anna Dominiczak	Wellcome Trust (WELLCOTR)	204820/Z/16/Z	Institute of Cardiovascular & Medical Sciences