SSRI antidepressants do not confound single photon emission computed tomography (SPECT) imaging studies using the 42 nicotinic acetylcholine receptor [123I]5-I-A85380 ligand: in vivo and in vitro evidence

Cavanagh, J., Patterson, J., Pimlott, S.L., Wyper, D.J. and Dewar, D. (2010) SSRI antidepressants do not confound single photon emission computed tomography (SPECT) imaging studies using the 42 nicotinic acetylcholine receptor [123I]5-I-A85380 ligand: in vivo and in vitro evidence. Synapse, 64(2), pp. 111-116. (doi:10.1002/syn.20705)

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Abstract

<b>Purpose</b>: In clinical molecular imaging the interaction between antidepressant medication and SPECT ligands is a significant potential confound. This study measured nAChR availability, as determined by SPECT imaging, on and off selective serotonin reuptake inhibitors in first episode depressed patients. <b>Methods</b>: Five patients in their first episode of major depressive disorder (MDD) on a single SSRI underwent [123I]5-I-A85380- SPECT neuroimaging prior to stopping their medication and again 6 weeks following medication cessation. Autoradiography of post mortem brain tissue with [125I]5-I-A85380 in the presence or absence of four commonly prescribed antidepressants was also assessed. <b>Results</b>: SSRI antidepressants did not affect the relative binding availability of 42 nicotinic acetylcholine receptors for the [123I]5-I-A85380 ligand in vivo. Radioligand binding in vitro was unaffected by a single, high pharmacological concentration of antidepressants. <b>Conclusion</b>: SPECT imaging studies using [123I]5-I-A85380 to measure 42 nAChR availability in depressed patients are unlikely to be confounded to a major degree by concurrent antidepressant medication.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Dewar, Dr Deborah and Patterson, Dr James and Wyper, Professor Dave and Pimlott, Dr Sally and Cavanagh, Professor Jonathan
Authors: Cavanagh, J., Patterson, J., Pimlott, S.L., Wyper, D.J., and Dewar, D.
Subjects:R Medicine > R Medicine (General)
College/School:College of Medical Veterinary and Life Sciences > Institute of Health and Wellbeing > Mental Health and Wellbeing
College of Medical Veterinary and Life Sciences > Institute of Neuroscience and Psychology
College of Medical Veterinary and Life Sciences > School of Medicine, Dentistry & Nursing > Clinical Specialities
Journal Name:Synapse
ISSN:0887-4476
ISSN (Online):1098-2396
Published Online:21 September 2009

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