Diverse myeloid cells are recruited to the developing and inflamed mammary gland

Wilson, G. J. , Fukuoka, A. , Vidler, F. and Graham, G. J. (2022) Diverse myeloid cells are recruited to the developing and inflamed mammary gland. Immunology, 165(2), pp. 206-218. (doi: 10.1111/imm.13430) (PMID:34775606)

Abstract

The immune system plays fundamental roles in the mammary gland, shaping developmental processes and controlling inflammation during infection and cancer. Here we reveal unanticipated heterogeneity in the myeloid cell compartment during development of virgin, pregnant, lactating and involuting mouse mammary glands, and in milk. We investigate the functional consequences of individual and compound chemokine receptor deficiency on cell recruitment. Diverse myeloid cell recruitment was also shown in models of sterile inflammation and bacterial infection. Strikingly, we have shown that inflammation and infection can alter the abundance of terminal end buds, a key developmental structure, within the pubertal mammary gland. This previously unknown effect of inflammatory burden during puberty could have important implications for understanding pubertal development.

• Item Type: Articles
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Suzuki, Dr Ayumi and Wilson, Dr Gillian and Vidler, Ms Francesca and Graham, Professor Gerard
• Authors: Wilson, G. J., Fukuoka, A., Vidler, F., and Graham, G. J.
• College/School: College of Medical Veterinary and Life Sciences > School of Infection & Immunity
• Research Centre: College of Medical Veterinary and Life Sciences > School of Infection & Immunity > Centre for Immunobiology
• Journal Name: Immunology
• Publisher: Wiley
• ISSN: 0019-2805
• ISSN (Online): 1365-2567
• Published Online: 14 November 2021
• Copyright Holders: Copyright © 2021 The Authors
• First Published: First published in Immunology 165(2): 206-218
• Publisher Policy: Reproduced under a Creative Commons License

Project Code	Award No	Project Name	Principal Investigator	Funder's Name	Funder Ref	Lead Dept
167227		Dissecting the chemokine basis for the orchestration of the in vivo inflammatory response	Gerard Graham	Wellcome Trust (WELLCOTR)	099251/Z/12/Z	III - Immunology
171627		The ACKR2-CCR2 axis in development and disease	Gerard Graham	Medical Research Council (MRC)	MR/M019764/1	III - Immunology