Diverse myeloid cells are recruited to the developing and inflamed mammary gland

Wilson, G. J. , Fukuoka, A., Vidler, F. and Graham, G. J. (2022) Diverse myeloid cells are recruited to the developing and inflamed mammary gland. Immunology, 165(2), pp. 206-218. (doi: 10.1111/imm.13430) (PMID:34775606)

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Abstract

The immune system plays fundamental roles in the mammary gland, shaping developmental processes and controlling inflammation during infection and cancer. Here we reveal unanticipated heterogeneity in the myeloid cell compartment during development of virgin, pregnant, lactating and involuting mouse mammary glands, and in milk. We investigate the functional consequences of individual and compound chemokine receptor deficiency on cell recruitment. Diverse myeloid cell recruitment was also shown in models of sterile inflammation and bacterial infection. Strikingly, we have shown that inflammation and infection can alter the abundance of terminal end buds, a key developmental structure, within the pubertal mammary gland. This previously unknown effect of inflammatory burden during puberty could have important implications for understanding pubertal development.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Vidler, Ms Francesca and Wilson, Dr Gillian
Authors: Wilson, G. J., Fukuoka, A., Vidler, F., and Graham, G. J.
College/School:College of Medical Veterinary and Life Sciences > Institute of Infection Immunity and Inflammation
Journal Name:Immunology
Publisher:Wiley
ISSN:0019-2805
ISSN (Online):1365-2567
Published Online:14 November 2021
Copyright Holders:Copyright © 2021 The Authors
First Published:First published in Immunology 165(2): 206-218
Publisher Policy:Reproduced under a Creative Commons License

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