GRADE guidance 24. Optimizing the integration of randomized and non-randomized studies in evidence syntheses of health interventions

Cuello-Garcia, C. A. et al. (2022) GRADE guidance 24. Optimizing the integration of randomized and non-randomized studies in evidence syntheses of health interventions. Journal of Clinical Epidemiology, 142, pp. 200-208. (doi: 10.1016/j.jclinepi.2021.11.026) (PMID:34800676) (PMCID:PMC8982640)

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Abstract

This is the 24th in the ongoing series of articles describing the GRADE approach for assessing the certainty of a body of evidence in systematic reviews and health technology assessments and how to move from evidence to recommendations in guidelines. Guideline developers and authors of systematic reviews and other evidence syntheses use randomized controlled studies (RCTs) and non-randomized studies of interventions (NRSI) as sources of evidence for questions about health interventions. RCTs with low risk of bias are the most trustworthy source of evidence for estimating relative effects of interventions because of protection against confounding and other biases. However, in several instances, NRSI can still provide valuable information as complementary, sequential, or replacement evidence for RCTs. In this article we offer guidance on the decision regarding when to search for and include either or both types of studies in systematic reviews to inform health recommendations. This work aims to help methodologists in review teams, technology assessors, guideline panelists, and anyone conducting evidence syntheses using GRADE.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Katikireddi, Professor Vittal
Creator Roles:
Katikireddi, S. V.["credit_typename_" not defined]
Authors: Cuello-Garcia, C. A., Santesso, N., Morgan, R. L., Verbeek, J., Thayer, K., Ansari, M. T., Meerpohl, J., Katikireddi, S. V., Brozek, J. L., Reeves, B., Murad, M. H., Falavigna, M., Mustafa, R., Regidor, D. L., Alexander, P. E., Garner, P., Akl, E. A., Guyatt, G., and Schünemann, H. J.
College/School:College of Medical Veterinary and Life Sciences > School of Health & Wellbeing > MRC/CSO SPHSU
Journal Name:Journal of Clinical Epidemiology
Publisher:Elsevier
ISSN:0895-4356
ISSN (Online):1878-5921
Published Online:17 November 2021
Copyright Holders:Copyright © 2021 The Authors
First Published:First published in Journal of Clinical Epidemiology 142: 200-208
Publisher Policy:Reproduced under a Creative Commons License

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