An ossifying landscape: materials and growth factor strategies for osteogenic signalling and bone regeneration

Dhawan, U., Jaffery, H., Salmeron-Sanchez, M. and Dalby, M. J. (2022) An ossifying landscape: materials and growth factor strategies for osteogenic signalling and bone regeneration. Current Opinion in Biotechnology, 73, pp. 355-363. (doi: 10.1016/j.copbio.2021.10.010) (PMID:34735985)

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Abstract

Breakthroughs in our understanding of the complex interplay between cellular nanoenvironment and biomolecular signalling pathways are facilitating development of targeted osteogenic platforms. As critical biomolecules for osteogenesis, growth factors stimulate osteogenesis by activating key genes and transcription factors. The first half of this review presents emerging interconnectedness and recent discoveries of osteogenic signalling pathways initiating from growth factors for example, bone morphogenetic protein 2 (BMP-2). To complement this, the second half of review proposes a number of strategies to induce osteogenesis which include metallic, organic implants, nanotopological environments as well as growth factor immobilization techniques. The drawbacks of traditional osteogenic implants and how these have been overcome by biomedical engineers in the recent years without producing side-effects have also been summarized.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Salmeron-Sanchez, Professor Manuel and Jaffery, Dr Hussain and Dhawan, Dr Udesh and Dalby, Professor Matthew
Creator Roles:
Dhawan, U.Conceptualization, Data curation, Writing – original draft, Writing – review and editing, Visualization
Jaffery, H.Conceptualization, Data curation, Writing – original draft, Writing – review and editing, Visualization
Salmeron-Sanchez, M.Conceptualization, Writing – review and editing, Supervision, Funding acquisition
Dalby, M. J.Conceptualization, Writing – review and editing, Supervision, Funding acquisition
Authors: Dhawan, U., Jaffery, H., Salmeron-Sanchez, M., and Dalby, M. J.
College/School:College of Medical Veterinary and Life Sciences > Institute of Molecular Cell and Systems Biology
College of Science and Engineering > School of Engineering > Biomedical Engineering
Journal Name:Current Opinion in Biotechnology
Publisher:Elsevier
ISSN:0958-1669
ISSN (Online):1879-0429
Published Online:01 November 2021

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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
307621HEALIKICKManuel Salmeron-SanchezEuropean Commission (EC)874889Institute of Molecular, Cell & Systems Biology