Dhawan, U. , Jaffery, H., Salmeron-Sanchez, M. and Dalby, M. J. (2022) An ossifying landscape: materials and growth factor strategies for osteogenic signalling and bone regeneration. Current Opinion in Biotechnology, 73, pp. 355-363. (doi: 10.1016/j.copbio.2021.10.010) (PMID:34735985)
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Abstract
Breakthroughs in our understanding of the complex interplay between cellular nanoenvironment and biomolecular signalling pathways are facilitating development of targeted osteogenic platforms. As critical biomolecules for osteogenesis, growth factors stimulate osteogenesis by activating key genes and transcription factors. The first half of this review presents emerging interconnectedness and recent discoveries of osteogenic signalling pathways initiating from growth factors for example, bone morphogenetic protein 2 (BMP-2). To complement this, the second half of review proposes a number of strategies to induce osteogenesis which include metallic, organic implants, nanotopological environments as well as growth factor immobilization techniques. The drawbacks of traditional osteogenic implants and how these have been overcome by biomedical engineers in the recent years without producing side-effects have also been summarized.
| Item Type: | Articles |
|---|---|
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Salmeron-Sanchez, Professor Manuel and Jaffery, Dr Hussain and Dhawan, Dr Udesh and Dalby, Professor Matthew |
| Creator Roles: | Dhawan, U.Conceptualization, Data curation, Writing – original draft, Writing – review and editing, Visualization Jaffery, H.Conceptualization, Data curation, Writing – original draft, Writing – review and editing, Visualization Salmeron-Sanchez, M.Conceptualization, Writing – review and editing, Supervision, Funding acquisition Dalby, M. J.Conceptualization, Writing – review and editing, Supervision, Funding acquisition |
| Authors: | Dhawan, U., Jaffery, H., Salmeron-Sanchez, M., and Dalby, M. J. |
| College/School: | College of Medical Veterinary and Life Sciences > School of Molecular Biosciences College of Science and Engineering > School of Engineering > Biomedical Engineering |
| Journal Name: | Current Opinion in Biotechnology |
| Publisher: | Elsevier |
| ISSN: | 0958-1669 |
| ISSN (Online): | 1879-0429 |
| Published Online: | 01 November 2021 |
| Copyright Holders: | Crown Copyright © 2021 |
| First Published: | First published in Current Opinion in Biotechnology 73: 355-363 |
| Publisher Policy: | Reproduced in accordance with the publisher copyright policy |
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