Microbiome and paediatric gut diseases

Gerasimidis, K. , Gkikas, K., Stewart, C., Neelis, E. and Svolos, V. (2021) Microbiome and paediatric gut diseases. Archives of Disease in Childhood, (doi: 10.1136/archdischild-2020-320875) (PMID:34716173) (Early Online Publication)

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Abstract

In the human gut resides a vast community of microorganisms which perform critical functions for the maintenance of whole body homeostasis. Changes in the composition and function of this community, termed microbiome, are believed to provoke disease onset, including non-communicable diseases. In this review, we debate the current evidence on the role of the gut microbiome in the pathogenesis, outcomes and management of paediatric gut disease. We conclude that even though the gut microbiome is altered in paediatric inflammatory bowel disease, coeliac disease, intestinal failure, necrotising enterocolitis and irritable bowel syndrome, there are currently very few implications for unravelling disease pathogenesis or guiding clinical practice. In the future, the gut microbiome may aid in disease differential diagnosis and prediction of clinical outcomes, and comprise a target for therapeutic interventions.

Item Type:Articles
Status:Early Online Publication
Refereed:Yes
Glasgow Author(s) Enlighten ID:Gerasimidis, Professor Konstantinos and Gkikas, Konstantinos and Svolos, Dr Vaios
Authors: Gerasimidis, K., Gkikas, K., Stewart, C., Neelis, E., and Svolos, V.
College/School:College of Medical Veterinary and Life Sciences > School of Medicine, Dentistry & Nursing
Journal Name:Archives of Disease in Childhood
Publisher:BMJ Publishing Group
ISSN:0003-9888
ISSN (Online):1468-2044
Published Online:29 October 2021
Copyright Holders:Copyright © 2021 The Authors
First Published:First published in Archives of Disease in Childhood 2021
Publisher Policy:Reproduced in accordance with the copyright policy of the publisher

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