Will advances in functional renal magnetic resonance imaging translate to the nephrology clinic?

Rankin, A. J. , Mayne, K., Allwood-Spiers, S., Hall Barrientos, P., Roditi, G., Gillis, K. A. and Mark, P. B. (2021) Will advances in functional renal magnetic resonance imaging translate to the nephrology clinic? Nephrology, (doi: 10.1111/nep.13985) (PMID:34724286) (Early Online Publication)

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Abstract

Characterizing structural and tissue abnormalities of the kidney is fundamental to understanding kidney disease. Functional multi-parametric renal magnetic resonance imaging (MRI) is a noninvasive imaging strategy whereby several sequences are employed within a single session to quantify renal perfusion, tissue oxygenation, fibrosis, inflammation, and oedema without using ionizing radiation. In this review, we discuss evidence surrounding its use in several clinical settings including acute kidney injury, chronic kidney disease, hypertension, polycystic kidney disease and around renal transplantation. Kidney size on MRI is already a validated measure for making therapeutic decisions in the setting of polycystic kidney disease. Functional MRI sequences, T1 mapping and apparent diffusion coefficient, can non-invasively quantify interstitial fibrosis and so may have a near-future role in the nephrology clinic to stratify the risk of progressive chronic kidney disease or transplant dysfunction. Beyond this, multi-parametric MRI may be used diagnostically, for example differentiating inflammatory versus ischaemic causes of renal dysfunction, but this remains to be proven. Changes in MRI properties of kidney parenchyma may be useful surrogate markers to use as end points in clinical trials to assess if drugs prevent renal fibrosis or alter kidney perfusion. Large, multi-centre studies of functional renal MRI are ongoing which aim to provide definitive answers as to its role in the management of patients with renal dysfunction.

Item Type:Articles
Status:Early Online Publication
Refereed:Yes
Glasgow Author(s) Enlighten ID:Roditi, Dr Giles and Mark, Professor Patrick and Gillis, Dr Keith and Rankin, Dr Alastair and Mayne, Dr Kaitlin and Hall Barrientos, Dr Pauline and Allwood-Spiers, Sarah
Authors: Rankin, A. J., Mayne, K., Allwood-Spiers, S., Hall Barrientos, P., Roditi, G., Gillis, K. A., and Mark, P. B.
College/School:College of Medical Veterinary and Life Sciences > Institute of Cardiovascular and Medical Sciences
College of Medical Veterinary and Life Sciences > School of Medicine, Dentistry & Nursing
Journal Name:Nephrology
Publisher:Wiley
ISSN:1320-5358
ISSN (Online):1440-1797
Published Online:01 November 2021
Copyright Holders:Copyright © 2021 Asian Pacific Society of Nephrology
First Published:First published in Nephrology 2021
Publisher Policy:Reproduced in accordance with the publisher copyright policy

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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
305405A clinical-pathological study into the diagnostic utility of multiparametric MRI in the setting of kidney transplant dysfunctionPatrick MarkKidney Research UK (KIDNEYRE)KS_IN_002_20180913CAMS - Cardiovascular Science