Exploring the impact of changes in neurogenic urinary incontinence frequency and condition-specific quality of life on preference-based outcomes

Hollingworth, W., Campbell, J.D., Kowalski, J., Ravelo, A., Girod, I., Briggs, A. and Sullivan, S.D. (2010) Exploring the impact of changes in neurogenic urinary incontinence frequency and condition-specific quality of life on preference-based outcomes. Quality of Life Research, 19(3), pp. 323-331. (doi: 10.1007/s11136-010-9590-z)

Abstract

<b>Purpose</b> Many trials do not measure quality-adjusted life years (QALYs). Therefore, decision analysts often map condition-specific outcomes to preference scores. We estimated the relationship between changes in preference scores and commonly reported condition-specific outcomes in patients with urinary incontinence (UI) due to neurogenic detrusor overactivity. <b>Methods</b> In 59 patients recruited to a neurogenic UI trial, clinical outcomes (UI episodes), condition-specific quality of life (Incontinence Quality of Life Instrument (I-QOL)), and SF-6D preference scores were measured at enrollment and 24 weeks. We used multiple linear regression to estimate the impact on SF-6D scores of 50; 50–99 and 100% reductions in UI episodes and a 10-point improvement in I-QOL. <b>Results</b> By 24 weeks, mean (95% CI) daily UI episodes fell by 0.85 (0.04, 1.3) and mean I-QOL scores improved by 18 (12, 24). SF-6D scores increased by 0.03 (0.003, 0.058), due to improvements in role limitations. A ≥ 50% reduction in UI episodes was achieved by 49% of patients and corresponded to a 0.09 (0.02, 0.16) SF-6D increase. A ≥ 10-point increase in I-QOL was attained by 65% of patients and was associated with a 0.05 (−0.02, 0.12) SF-6D increase. <b>Conclusions</b> These estimates provide preliminary data for decision analysts wishing to map neurogenic UI outcomes to preference scores.

• Item Type: Articles
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Briggs, Professor Andrew
• Authors: Hollingworth, W., Campbell, J.D., Kowalski, J., Ravelo, A., Girod, I., Briggs, A., and Sullivan, S.D.
• Subjects: R Medicine > R Medicine (General)
• College/School: College of Medical Veterinary and Life Sciences > School of Health & Wellbeing > Health Economics and Health Technology Assessment; College of Medical Veterinary and Life Sciences > School of Medicine, Dentistry & Nursing > Centre for Population and Health Sciences
• Journal Name: Quality of Life Research
• ISSN: 0962-9343
• ISSN (Online): 1573-2649