An appraisal of antigen identification and IgG effector functions driving host immune responses in multiple sclerosis

Yu, X., Zizzo, Z. and Kennedy, P. G.E. (2021) An appraisal of antigen identification and IgG effector functions driving host immune responses in multiple sclerosis. Multiple Sclerosis and Related Disorders, 56, 103328. (doi: 10.1016/j.msard.2021.103328) (PMID:34666240)

[img] Text
257000.pdf - Accepted Version
Restricted to Repository staff only until 12 October 2022.
Available under License Creative Commons Attribution Non-commercial No Derivatives.

570kB

Abstract

Increased immunoglobulin G (IgG) antibodies and oligoclonal bands (OCB) are the most characteristic features of multiple sclerosis (MS), a neuroinflammatory demyelinating disease with neurodegeneration at chronic stages. OCB are shown to be associated with disease activity and brain atrophy. Despite intensive research over the last several decades, the antigen specificities of the IgG in MS have remained elusive. We present evidence which supports that intrathecal IgG is not driven by antigen-stimulation, therefore provide reasoning for failed MS antigen identification. Further, the presence of co-deposition of IgG and activated complement products in MS lesions suggest that the IgG effector functions may play a critical role in disease pathogenesis.

Item Type:Articles
Additional Information:This work was supported by the Department of Neurosurgery Research Funds, University of Colorado Anschutz Medical Campus with additional support from the National Institutes of Health [grant number 4R33MH118174-03].
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Kennedy, Professor Peter
Creator Roles:
Kennedy, P. G.E.Writing – review and editing
Authors: Yu, X., Zizzo, Z., and Kennedy, P. G.E.
College/School:College of Medical Veterinary and Life Sciences > School of Psychology & Neuroscience
Journal Name:Multiple Sclerosis and Related Disorders
Publisher:Elsevier
ISSN:2211-0348
ISSN (Online):2211-0356
Published Online:12 October 2021
Copyright Holders:Copyright © 2021 Elsevier B.V.
First Published:First published in Multiple Sclerosis and Related Disorders 56: 103328
Publisher Policy:Reproduced in accordance with the publisher copyright policy

University Staff: Request a correction | Enlighten Editors: Update this record