An appraisal of antigen identification and IgG effector functions driving host immune responses in multiple sclerosis

Yu, X., Zizzo, Z. and Kennedy, P. G.E. (2021) An appraisal of antigen identification and IgG effector functions driving host immune responses in multiple sclerosis. Multiple Sclerosis and Related Disorders, 56, 103328. (doi: 10.1016/j.msard.2021.103328) (PMID:34666240)

Abstract

Increased immunoglobulin G (IgG) antibodies and oligoclonal bands (OCB) are the most characteristic features of multiple sclerosis (MS), a neuroinflammatory demyelinating disease with neurodegeneration at chronic stages. OCB are shown to be associated with disease activity and brain atrophy. Despite intensive research over the last several decades, the antigen specificities of the IgG in MS have remained elusive. We present evidence which supports that intrathecal IgG is not driven by antigen-stimulation, therefore provide reasoning for failed MS antigen identification. Further, the presence of co-deposition of IgG and activated complement products in MS lesions suggest that the IgG effector functions may play a critical role in disease pathogenesis.

• Item Type: Articles
• Additional Information: This work was supported by the Department of Neurosurgery Research Funds, University of Colorado Anschutz Medical Campus with additional support from the National Institutes of Health [grant number 4R33MH118174-03].
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Kennedy, Professor Peter

Creator Roles

Kennedy, P. G.E.: Writing – review and editing

• Authors: Yu, X., Zizzo, Z., and Kennedy, P. G.E.
• College/School: College of Medical Veterinary and Life Sciences > School of Psychology & Neuroscience
• Journal Name: Multiple Sclerosis and Related Disorders
• Publisher: Elsevier
• ISSN: 2211-0348
• ISSN (Online): 2211-0356
• Published Online: 12 October 2021
• Copyright Holders: Copyright © 2021 Elsevier B.V.
• First Published: First published in Multiple Sclerosis and Related Disorders 56: 103328
• Publisher Policy: Reproduced in accordance with the publisher copyright policy