Host-cell invasion by malaria parasites: insights from Plasmodium and Toxoplasma

Baum, J., Gilberger, T.W., Frischknecht, F. and Meissner, M. (2008) Host-cell invasion by malaria parasites: insights from Plasmodium and Toxoplasma. Trends in Parasitology, 24(12), pp. 557-563. (doi:10.1016/j.pt.2008.08.006)

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Abstract

Recent years have seen tremendous progress in our understanding of malaria parasite molecular biology. To a large extent, this progress follows significant developments in genetic, molecular and chemical tools available to study the malaria parasites and related Apicomplexa, in particular Toxoplasma gondii. One area of major advancement has been in understanding parasite host-cell invasion, a process that utilizes several essential molecular mechanisms that are conserved across the different lifecycle stages. Here, we summarize some of the most recent experimental data that shed light on the events underlying preparation and execution of malaria parasite invasion and how these insights might relate to the development of new antimalarial drugs.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Meissner, Professor Markus
Authors: Baum, J., Gilberger, T.W., Frischknecht, F., and Meissner, M.
Subjects:Q Science > Q Science (General)
College/School:College of Medical Veterinary and Life Sciences
College of Medical Veterinary and Life Sciences > Institute of Infection Immunity and Inflammation
Journal Name:Trends in Parasitology
ISSN:1471-4922
ISSN (Online):1471-5007
Published Online:01 October 2008

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