Black tea reduces uric acid and C-reactive protein levels in humans susceptible to cardiovascular diseases

Bahorun, T., Luximon-Ramma, A., Gunness, T.K., Sookar, D., Bhoyroo, S., Jugessur, R., Reebye, D., Googoolye, K., Crozier, A. and Aruoma, O.I. (2010) Black tea reduces uric acid and C-reactive protein levels in humans susceptible to cardiovascular diseases. Toxicology, 278(1), pp. 68-74. (doi:10.1016/j.tox.2009.11.024)

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Abstract

The effect of black tea on the level of uric acid (UA) and C-reactive proteins (CRP) in humans susceptible to ischemic heart diseases was assessed in a prospective randomized controlled study. The study group consumed 9 g of black tea (equivalent to three cups of tea) daily for 12 weeks without additives followed by a 3-week wash-out (with control group consuming equivalent volume of hot water). Black tea consumption induced a highly significant decrease in the high uric acid baseline groups >6 mg/dL by 8.5%; p < 0.05. For men and women in the base line group >7 mg/dL, the decrease was 9.4% and 7.1%, respectively. In the low baseline serum uric acid levels there was a non-significant increase of 3.7% and 15% in men and women, respectively. C-reactive protein in the high risk group >3 mg/L was significantly decreased by 53.4% and 41.1% in men and women, respectively. For the non-supplemented group in this range the changes were 3.7% decrease for men and 2.9% increase for women. Tea supplementation-associated decrease in plasma uric acid and C-reactive protein levels may benefit humans at high risk of cardiovascular events and may augment drug therapy.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Crozier, Professor Alan
Authors: Bahorun, T., Luximon-Ramma, A., Gunness, T.K., Sookar, D., Bhoyroo, S., Jugessur, R., Reebye, D., Googoolye, K., Crozier, A., and Aruoma, O.I.
Subjects:R Medicine > R Medicine (General)
College/School:College of Medical Veterinary and Life Sciences
Journal Name:Toxicology
ISSN:0300-483X
Published Online:04 December 2009

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