Patterns of divergence in the vCXCL and vGPCR gene clusters in primate cytomegalovirus genomes

Alcendor, D.J., Zong, J.C., Dolan, A., Gatherer, D., Davison, A.J. and Hayward, G.S. (2009) Patterns of divergence in the vCXCL and vGPCR gene clusters in primate cytomegalovirus genomes. Virology, 395(1), pp. 21-32. (doi:10.1016/j.virol.2009.09.002) (PMID:19818982) (PMCID:PMC2846823)

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Abstract

Primate cytomegalovirus (CMV) genomes contain tandemly repeated gene clusters Putatively encoding divergent CXC chemokine ligand-like proteins (vCXCLs) and G protein-coupled receptor-like proteins (vGPCRs). In human, chimpanzee and rhesus CMVs, respectively, the vCXCL cluster contains two, three and six genes, and the vGPCR cluster contains two, two and five genes. We report that (i) green monkey CMV strains fall into two groups, containing either eight and five genes or seven and six genes in the respective clusters, and (ii) owl monkey CMV has two and zero genes. Phylogenetic analysis suggested that the vCXCL cluster evolved from a CXCL chemokine gene (probably GRO-alpha) that was captured in an incompletely spliced form by an ancestor of Old and New World primate CMVs, and that the vGPCR cluster evolved from a GPCR gene captured by an Old World primate CMV. Both clusters appear to have evolved via complex duplication and deletion events.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Dolan, Mr Aidan and Gatherer, Dr Derek and Davison, Professor Andrew
Authors: Alcendor, D.J., Zong, J.C., Dolan, A., Gatherer, D., Davison, A.J., and Hayward, G.S.
Subjects:Q Science > QR Microbiology > QR355 Virology
Q Science > QH Natural history > QH426 Genetics
College/School:College of Medical Veterinary and Life Sciences > Institute of Infection Immunity and Inflammation
Journal Name:Virology
ISSN:0042-6822
ISSN (Online):1096-0341
Published Online:09 October 2009
Copyright Holders:Copyright © 2009 Elsevier Inc.
First Published:First published Virology 395(1):21-32
Publisher Policy:Reproduced in accordance with the copyright policy of the publisher

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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
656321Genomics of human cytomegalovirusAndrew DavisonMedical Research Council (MRC)MC_UU_12014/3MVLS III - CENTRE FOR VIRUS RESEARCH