Everett, R.D. (2010) Depletion of CoREST does not improve the replication of ICP0 null mutant herpes simplex virus type 1. Journal of Virology, 84(7), pp. 3695-3698. (doi: 10.1128/JVI.00021-10)
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Publisher's URL: http://dx.doi.org/10.1128/JVI.00021-10
Abstract
It has been proposed that the cellular co-repressor protein CoREST is involved in repressing herpes simplex virus type 1 (HSV-1) infection in the absence of the viral regulatory protein ICP0. This proposal predicts that depletion of CoREST should improve the plaque forming efficiency and replication of ICP0-null mutant virus. To test this hypothesis, human HepaRG cells that are highly depleted of CoREST were isolated using RNA interference technology. Depletion of CoREST had no affect on the replication of ICP0 null mutant HSV-1, demonstrating that CoREST does not play an influential role in regulating HSV-1 infection in this cell type.
| Item Type: | Articles |
|---|---|
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Everett, Professor Roger |
| Authors: | Everett, R.D. |
| Subjects: | Q Science > QR Microbiology > QR355 Virology |
| College/School: | College of Medical Veterinary and Life Sciences > School of Infection & Immunity |
| Journal Name: | Journal of Virology |
| Journal Abbr.: | J. Virol. |
| ISSN: | 0022-538X |
| ISSN (Online): | 1098-5514 |
| Published Online: | 27 January 2010 |
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