Metabolomic systems biology of trypanosomes

Barrett, M.P. , Bakker, B.M. and Breitling, R. (2010) Metabolomic systems biology of trypanosomes. Parasitology, 137(9), pp. 1285-1290. (doi:10.1017/S003118201000017X)

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Abstract

Metabolomics analysis, which aims at the systematic identification and quantification of all metabolites in biological systems, is emerging as a powerful new tool to identify biomarkers of disease, report on cellular responses to environmental perturbation, and to identify the targets of drugs. Here we discuss recent developments in metabolomic analysis, from the perspective of trypanosome research, highlighting remaining challenges and the most promising areas for future research.

Item Type:Articles
Keywords:Metabolomics, mass spectrometry, Orbitrap; ab initio networks, Trypanosoma brucei
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Breitling, Professor Rainer and Barrett, Professor Michael
Authors: Barrett, M.P., Bakker, B.M., and Breitling, R.
Subjects:Q Science > QR Microbiology
College/School:College of Medical Veterinary and Life Sciences > Institute of Infection Immunity and Inflammation
College of Medical Veterinary and Life Sciences > Institute of Molecular Cell and Systems Biology
Journal Name:Parasitology
Publisher:Cambridge University Press
ISSN:0031-1820
ISSN (Online):1469-8161
Published Online:17 February 2010
Copyright Holders:Copyright © 2010 Cambridge University Press
First Published:First published in Parasitology 137(9):1285-1290
Publisher Policy:Reproduced in accordance with the copyright policy of the publisher

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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
522081The silicon trypanosome (SilicoTryp)Michael BarrettBiotechnology and Biological Sciences Research Council (BBSRC)BB/I004599/1Infection Immunity and Inflammation Life Sciences