Enlighten
Research publications by members of the University of Glasgow
home > services > Enlighten

Effect of inflammation on measures of antioxidant status in patients with non-small cell lung cancer

Talwar, D., Ha, T., Scott, H., Cooney, J., Fell, G., O'Reilly, D., Lean, M., and McMillan, D. (1997) Effect of inflammation on measures of antioxidant status in patients with non-small cell lung cancer. American Journal of Clinical Nutrition, 66 . pp. 1283-1285. ISSN 0002-9165

Full text not currently available from Enlighten.

Abstract

This study examined the effect of an inflammatory response on measures of antioxidant status in patients with non-small cell lung cancer (NSCLC). In healthy, control subjects (n = 13) and NSCLC patients (n = 22) fasting concentrations of albumin, C-reactive protein, cholesterol, and the antioxidants alpha-tocopherol, retinol, lutein, lycopene, and alpha- and beta-carotene were measured. The two groups were similar in terms of age, sex, and body mass index. However, the cancer group had an inflammatory response as evidenced by significantly increased C- reactive protein concentrations. Concentrations of all the measured antioxidants of the NSCLC group were significantly lower than those of the control group (P < 0.01). The lowest concentrations were those of the carotenoids lycopene and alpha- and beta-carotene. In the cancer group there were significant negative correlations between concentrations of C-reactive protein and retinol (r = -0.682, P < 0.01), alpha-tocopherol (r = -0.464, P < 0.05), and lutein (r = -0.599, P < 0.01). The results of this study have implications for the interpretation of circulating antioxidant concentrations in patients with NSCLC.

Item Type:Article
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:McMillan, Prof Donald
Authors: Talwar, D., Ha, T., Scott, H., Cooney, J., Fell, G., O'Reilly, D., Lean, M., and McMillan, D.
Subjects:R Medicine > RC Internal medicine > RC0254 Neoplasms. Tumors. Oncology (including Cancer)
College/School:College of Medical Veterinary and Life Sciences > School of Medicine > Clinical Specialities
Journal Name:American Journal of Clinical Nutrition
ISSN:0002-9165
ISSN (Online):1938-3207

University Staff: Request a correction | Enlighten Editors: Update this record