Systematic review of tumour budding and association with common mutations in patients with colorectal cancer

Hatthakarnkul, P. , Quinn, J. A. , Matly, A. A. M., Ammar, A. , Van Wyk, H. C. , McMillan, D. C. and Edwards, J. (2021) Systematic review of tumour budding and association with common mutations in patients with colorectal cancer. Critical Reviews in Oncology/Hematology, 167, 103490. (doi: 10.1016/j.critrevonc.2021.103490) (PMID:34619332)

Abstract

Introduction: Despite a well-known prognostic role in colorectal cancer, the genomic profiling of tumour budding remains to be elucidated. We aim to review the association of common mutations with tumour budding. Methods: A systematic review of studies relating to tumour budding and genetic mutation in CRC was performed. The relationship between mutational status and tumour budding was evaluated using meta-analysis. Results: A total of 6153 patients from 17 articles were included. According to the meta-analysis, high-grade tumour budding was significantly associated with KRAS mutation (OR = 1.52, 95%CI: 1.13-2.02, P = 0.005) and MSS/pMMR (OR = 2.06, 95%CI: 1.42-2.97, P = 0.0001). Conclusion: The significant association between high-grade tumour budding and mutated KRAS or MSS/pMMR may suggest a role of these mutations in the development of the tumour budding phenotype and be useful for stratifying patient outcome in CRC.

• Item Type: Articles
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Quinn, Dr Jean and Edwards, Professor Joanne and Matly, Mrs Amna and Hatthakarnkul, Phimmada and McMillan, Professor Donald and Ammar, Dr Aula and Van Wyk, Dr Hester
• Authors: Hatthakarnkul, P., Quinn, J. A., Matly, A. A. M., Ammar, A., Van Wyk, H. C., McMillan, D. C., and Edwards, J.
• College/School: College of Medical Veterinary and Life Sciences; College of Medical Veterinary and Life Sciences > School of Cancer Sciences; College of Medical Veterinary and Life Sciences > School of Medicine, Dentistry & Nursing
• Journal Name: Critical Reviews in Oncology/Hematology
• Publisher: Elsevier
• ISSN: 1040-8428
• ISSN (Online): 1879-0461
• Published Online: 04 October 2021
• Copyright Holders: Copyright © Crown Copyright 2021
• First Published: First published in Critical Reviews in Oncology/Hematology 167: 103490
• Publisher Policy: Reproduced in accordance with the publisher copyright policy